Journal article
From Silk Spinning to 3D Printing: Polymer Manufacturing using Directed Hierarchical Molecular Assembly
Advanced healthcare materials, Vol.9(15), pp.1-17
08/01/2020
DOI: 10.1002/adhm.201901552
PMCID: PMC7415583
PMID: 32109007
Abstract
Silk spinning offers an evolution-based manufacturing strategy for industrial polymer manufacturing, yet remains largely inaccessible as the manufacturing mechanisms in biological and synthetic systems, especially at the molecular level, are fundamentally different. The appealing characteristics of silk spinning include the sustainable sourcing of the protein material, the all-aqueous processing into fibers, and the unique material properties of silks in various formats. Substantial progress has been made to mimic silk spinning in artificial manufacturing processes, despite the gap between natural and artificial systems. This report emphasizes the universal spinning conditions utilized by both spiders and silkworms to generate silk fibers in nature, as a scientific and technical framework for directing molecular assembly into high-performance structures. The preparation of regenerated silk feedstocks and mimicking native spinning conditions in artificial manufacturing are discussed, as is progress and challenges in fiber spinning and 3D printing of silk-composites. Silk spinning is a biomimetic model for advanced and sustainable artificial polymer manufacturing, offering benefits in biomedical applications for tissue scaffolds and implantable devices.
Details
- Title: Subtitle
- From Silk Spinning to 3D Printing: Polymer Manufacturing using Directed Hierarchical Molecular Assembly
- Creators
- Xuan Mu - Tufts UniversityVincent Fitzpatrick - Tufts UniversityDavid L. Kaplan - Tufts University
- Resource Type
- Journal article
- Publication Details
- Advanced healthcare materials, Vol.9(15), pp.1-17
- DOI
- 10.1002/adhm.201901552
- PMID
- 32109007
- PMCID
- PMC7415583
- NLM abbreviation
- Adv Healthc Mater
- ISSN
- 2192-2640
- eISSN
- 2192-2659
- Publisher
- Wiley
- Number of pages
- 17
- Grant note
- P41EB002520; R01EB021264; R01NS092847; U01EB014976 / NIH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA FA9550-17-1-0333 / Air Force Office of Scientific Research; United States Department of Defense; Air Force Office of Scientific Research (AFOSR)
- Language
- English
- Date published
- 08/01/2020
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering
- Record Identifier
- 9984276457102771
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