Journal article
From compliment to insult: genetics of the complement system in physiology and disease in the human retina
Human molecular genetics, Vol.26(R1), pp.R51-R57
05/08/2017
DOI: 10.1093/hmg/ddx181
PMCID: PMC5886463
PMID: 28482029
Abstract
Age-related macular degeneration (AMD) is a major cause of visual impairment that affects the central retina. Genome wide association studies and candidate gene screens have identified members of the complement pathway as contributing to the risk of AMD. In this review, we discuss the complement system, its importance in retinal development and normal physiology, how its dysregulation may contribute to disease, and how it might be targeted to prevent damage to the aging choriocapillaris in AMD.
Details
- Title: Subtitle
- From compliment to insult: genetics of the complement system in physiology and disease in the human retina
- Creators
- Robert F Mullins - University of Iowa, Ophthalmology and Visual SciencesAlasdair N WarwickElliott H Sohn - University of Iowa, Ophthalmology and Visual SciencesAndrew J Lotery
- Resource Type
- Journal article
- Publication Details
- Human molecular genetics, Vol.26(R1), pp.R51-R57
- Publisher
- Oxford University Press; England
- DOI
- 10.1093/hmg/ddx181
- PMID
- 28482029
- PMCID
- PMC5886463
- ISSN
- 1460-2083
- eISSN
- 1460-2083
- Grant note
- R01 EY024605 / NEI NIH HHS R01 EY026547 / NEI NIH HHS P30 EY025580 / NEI NIH HHS
- Language
- English
- Date published
- 05/08/2017
- Academic Unit
- Ophthalmology and Visual Sciences
- Record Identifier
- 9983735794302771
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