Journal article
From membrane receptors to protein synthesis and actin cytoskeleton: Mechanisms underlying long lasting forms of synaptic plasticity
Seminars in cell & developmental biology, Vol.95, pp.120-129
11/01/2019
DOI: 10.1016/j.semcdb.2019.01.006
PMCID: 6625948
PMID: 30634048
Abstract
Synaptic plasticity, the activity dependent change in synaptic strength, forms the molecular foundation of learning and memory. Synaptic plasticity includes structural changes, with spines changing their size to accomodate insertion and removal of postynaptic receptors, which are correlated with functional changes. Of particular relevance for memory storage are the long lasting forms of synaptic plasticity which are protein synthesis dependent. Due to the importance of spine structural plasticity and protein synthesis, this review focuses on the signaling pathways that connect synaptic stimulation with regulation of protein synthesis and remodeling of the actin cytoskeleton. We also review computational models that implement novel aspects of molecular signaling in synaptic plasticity, such as the role of neuromodulators and spatial microdomains, as well as highlight the need for computational models that connect activation of memory kinases with spine actin dynamics.
Details
- Title: Subtitle
- From membrane receptors to protein synthesis and actin cytoskeleton: Mechanisms underlying long lasting forms of synaptic plasticity
- Creators
- Joanna Jedrzejewska-Szmek - Polish Academy of SciencesKim T. Blackwell - George Mason University
- Resource Type
- Journal article
- Publication Details
- Seminars in cell & developmental biology, Vol.95, pp.120-129
- DOI
- 10.1016/j.semcdb.2019.01.006
- PMID
- 30634048
- PMCID
- 6625948
- NLM abbreviation
- Semin Cell Dev Biol
- ISSN
- 1084-9521
- eISSN
- 1096-3634
- Publisher
- Elsevier
- Number of pages
- 10
- Grant note
- 1515686 / NIH-NSF CRCNS program through NSF R01DA03889 / NIH-NSF CRCNS program through NIDA R01AA016022 / NIH-NSF CRCNS program through NIAAA R01AA016022 / NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute on Alcohol Abuse & Alcoholism (NIAAA) R01DA003889 / NATIONAL INSTITUTE ON DRUG ABUSE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute on Drug Abuse (NIDA); European Commission
- Language
- English
- Date published
- 11/01/2019
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Iowa Neuroscience Institute
- Record Identifier
- 9984446552002771
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