From regulation to ruin: a rogue sigma factor causes cell death in Bacillus subtilis

Amy H. Camp; Craig D. Ellermeier

doi:10.1128/jb.00203-23

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From regulation to ruin: a rogue sigma factor causes cell death in Bacillus subtilis

Journal article

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From regulation to ruin: a rogue sigma factor causes cell death in Bacillus subtilis

Amy H. Camp and Craig D. Ellermeier

Journal of bacteriology, Vol.205(10), e00203-23

10/26/2023

DOI: 10.1128/jb.00203-23

PMCID: PMC10601719

PMID: 37795990

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Abstract

ABSTRACT A rogue, plasmid-encoded sigma factor that kills Bacillus subtilis is the focus of a new study by A. T. Burton, D. Pospíšilová, P. Sudzinová, E. V. Snider, A. M. Burrage, L. Krásný, and D. B. Kearns (J Bacteriol 205:e00112-23, 2023, https://doi.org/10.1128/jb.00112-23 ). The authors demonstrate that SigN is toxic in its own right, causing cell death by potently outcompeting the housekeeping sigma factor for access to RNA polymerase.

Details

Title: Subtitle: From regulation to ruin: a rogue sigma factor causes cell death in Bacillus subtilis
Creators: Amy H. Camp - Mount Holyoke College
Craig D. Ellermeier - University of Iowa
Contributors: Tina M. Henkin (Editor)
Resource Type: Journal article
Publication Details: Journal of bacteriology, Vol.205(10), e00203-23
DOI: 10.1128/jb.00203-23
PMID: 37795990
PMCID: PMC10601719
NLM abbreviation: J Bacteriol
ISSN: 0021-9193
eISSN: 1098-5530
Language: English
Electronic publication date: 10/05/2023
Date published: 10/26/2023
Academic Unit: Microbiology and Immunology
Record Identifier: 9984476432102771

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