Journal article
Frontal P300 decrements, alcohol dependence, and antisocial personality disorder
Biological psychiatry (1969), Vol.47(12), pp.1064-1071
2000
DOI: 10.1016/S0006-3223(99)00317-0
PMID: 10862806
Abstract
Background: The purpose of this study was to examine the independent and interactive effects of alcohol dependence, antisocial personality disorder (ASPD), and age on brain function.
Methods: P300 event-related potentials (ERPs) were recorded from 393 alcohol-dependent and 170 non–alcohol-dependent adults while they performed a visual oddball task. The two subject groups were further subdivided based upon age and the presence/absence of ASPD.
Results: Alcohol dependence was associated with a significant P300 amplitude decrement at anterior electrode sites only. Antisocial personality disorder was also associated with reduced P300 amplitudes at anterior electrode sites; however, the effects were only significant among subjects 30 years of age or younger. To validate this association between ASPD and P300 amplitude a correlational analysis was performed; the correlation between anterior P300 amplitude and the total number of childhood conduct disorder and adult ASPD symptoms was significant.
Conclusions: The P300 amplitude decrement found at anterior electrode sites among subjects with ASPD is consistent with the results of numerous ERP, neuroimaging, or neuropsychologic studies of anterior brain function. Our study is unique in suggesting that the effects of ASPD on anterior brain function are best detected during early adulthood. The study also suggests that the detrimental neurophysiologic effects of alcohol dependence predominantly involve the anterior brain.
Details
- Title: Subtitle
- Frontal P300 decrements, alcohol dependence, and antisocial personality disorder
- Creators
- Laura Costa - Alcohol Research Center, Department of Psychiatry, University of Connecticut School of Medicine, Farmington, Connecticut, USA (LC, LB, VH)Lance Bauer - Alcohol Research Center, Department of Psychiatry, University of Connecticut School of Medicine, Farmington, Connecticut, USA (LC, LB, VH)Samuel Kuperman - Division of Child Psychiatry, University of Iowa Health Center, Iowa City, Iowa, USA (SK)Bernice Porjesz - Department of Psychiatry, State University of New York Health Science Center, Brooklyn, New York, USA (BP, HB)Sean O’Connor - Department of Psychiatry, Indiana University School of Medicine, Indianapolis, Indiana, USA (SO)Victor Hesselbrock - Alcohol Research Center, Department of Psychiatry, University of Connecticut School of Medicine, Farmington, Connecticut, USA (LC, LB, VH)John Rohrbaugh - Division of Family Studies, Washington University, St. Louis, Missouri, USA (JR)Henri Begleiter - Department of Psychiatry, State University of New York Health Science Center, Brooklyn, New York, USA (BP, HB)
- Resource Type
- Journal article
- Publication Details
- Biological psychiatry (1969), Vol.47(12), pp.1064-1071
- Publisher
- Elsevier Inc
- DOI
- 10.1016/S0006-3223(99)00317-0
- PMID
- 10862806
- ISSN
- 0006-3223
- eISSN
- 1873-2402
- Language
- English
- Date published
- 2000
- Academic Unit
- Psychiatry; Stead Family Department of Pediatrics
- Record Identifier
- 9984004099502771
Metrics
13 Record Views