Journal article
Frontal preparatory neural oscillations associated with cognitive control: A developmental study comparing young adults and adolescents
NeuroImage (Orlando, Fla.), Vol.136, pp.139-148
08/01/2016
DOI: 10.1016/j.neuroimage.2016.05.017
PMCID: PMC4914451
PMID: 27173759
Abstract
Functional magnetic resonance imaging (fMRI) studies suggest that age-related changes in the frontal cortex may underlie developmental improvements in cognitive control. In the present study we used magnetoencephalography (MEG) to identify frontal oscillatory neurodynamics that support age-related improvements in cognitive control during adolescence. We characterized the differences in neural oscillations in adolescents and adults during the preparation to suppress a prepotent saccade (antisaccade trials—AS) compared to preparing to generate a more automatic saccade (prosaccade trials—PS). We found that for adults, AS were associated with increased beta-band (16–38Hz) power in the dorsal lateral prefrontal cortex (DLPFC), enhanced alpha- to low beta-band (10–18Hz) power in the frontal eye field (FEF) that predicted performance, and increased cross-frequency alpha-beta (10–26Hz) amplitude coupling between the DLPFC and the FEF. Developmental comparisons between adults and adolescents revealed similar engagement of DLPFC beta-band power but weaker FEF alpha-band power, and lower cross-frequency coupling between the DLPFC and the FEF in adolescents. These results suggest that lateral prefrontal neural activity associated with cognitive control is adult-like by adolescence; the development of cognitive control from adolescence to adulthood is instead associated with increases in frontal connectivity and strengthening of inhibition signaling for suppressing task-incompatible processes.
•Antisaccades increased beta-band power in DLPFC and alpha-band power in FEF.•Prestimulus FEF alpha-band power predicted performance on the antisaccade task.•Adolescents showed weaker alpha-band power in FEF.•Adolescents showed reduced beta-alpha amplitude coupling between DPLFC and FEF.
Details
- Title: Subtitle
- Frontal preparatory neural oscillations associated with cognitive control: A developmental study comparing young adults and adolescents
- Creators
- Kai Hwang - Helen Wills Neuroscience Institute, University of California Berkeley, Berkeley, CA, United StatesAvniel S Ghuman - Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, United StatesDara S Manoach - Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United StatesStephanie R Jones - Department of Neuroscience, Brown University, Providence, RI, United StatesBeatriz Luna - Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, United States
- Resource Type
- Journal article
- Publication Details
- NeuroImage (Orlando, Fla.), Vol.136, pp.139-148
- DOI
- 10.1016/j.neuroimage.2016.05.017
- PMID
- 27173759
- PMCID
- PMC4914451
- NLM abbreviation
- Neuroimage
- ISSN
- 1053-8119
- eISSN
- 1095-9572
- Publisher
- Elsevier Inc
- Grant note
- DOI: 10.13039/100000025, name: National Institutes of Mental Health, award: R01 MH067924; name: MEG Research Seed Fund from the UPMC-Brain Mapping Center
- Language
- English
- Date published
- 08/01/2016
- Academic Unit
- Psychiatry; Psychological and Brain Sciences; Iowa Neuroscience Institute
- Record Identifier
- 9984002342302771
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