Frontal theta and beta oscillations during lower-limb movement in Parkinson’s disease

Arun Singh; Rachel C Cole; Arturo I Espinoza; Darin Brown; James F Cavanagh; Nandakumar S Narayanan

doi:10.1016/j.clinph.2019.12.399

Back

Frontal theta and beta oscillations during lower-limb movement in Parkinson’s disease

Journal article

Peer reviewed

Frontal theta and beta oscillations during lower-limb movement in Parkinson’s disease

Arun Singh, Rachel C Cole, Arturo I Espinoza, Darin Brown, James F Cavanagh and Nandakumar S Narayanan

Clinical neurophysiology, Vol.131(3), pp.694-702

03/2020

DOI: 10.1016/j.clinph.2019.12.399

PMID: 31991312

Files and links (1)

url

https://www.ncbi.nlm.nih.gov/pmc/articles/8112379View

Open Access

Abstract

•Frontal theta and beta rhythms were associated with cognitive and motor functions.•Gait dysfunction involves reduced theta and increased beta power in Parkinson’s disease.•PDFOG+ pedaled with reduced speed compared to PDFOG− patients and controls. Patients with Parkinson’s disease (PD) have deficits in lower-limb functions such as gait, which involves both cognitive and motor dysfunction. In PD, theta and beta brain rhythms are associated with cognitive and motor functions, respectively. We tested the hypothesis that PD patients with lower-limb abnormalities would exhibit abnormal theta and beta rhythms in the mid-frontal cortical region during lower-limb action. This study included thirty-nine participants; 13 PD patients with FOG (PDFOG+), 13 without FOG (PDFOG-), and 13 demographically-matched controls. We recorded scalp electroencephalograms (EEG) during a lower-limb pedaling motor task, which required intentional initiation and stopping of a motor movement. FOG scores were correlated with disease severity and cognition. PDFOG+ patients pedaled with reduced speed and decreased acceleration compared to PDFOG− patients and controls. PDFOG+ patients exhibited attenuated theta-band (4–8 Hz) power and increased beta-band (13–30 Hz) power at mid-frontal electrode Cz during pedaling. Frontal theta- and beta-band oscillations also correlated with motor and cognitive deficits. Frontal theta and beta oscillations are predictors of lower-limb motor symptoms in PD and could be used to design neuromodulation for PD-related lower-limb abnormalities. These data provide insight into mechanisms of lower-limb dysfunction in PD with FOG.

Oscillations

Freezing of gait

Lower-limb movement

Frontal region

Parkinson’s disease

Details

Title: Subtitle: Frontal theta and beta oscillations during lower-limb movement in Parkinson’s disease
Creators: Arun Singh - Neurology Department, University of Iowa, Iowa City, IA, USA
Rachel C Cole - Neurology Department, University of Iowa, Iowa City, IA, USA
Arturo I Espinoza - Neurology Department, University of Iowa, Iowa City, IA, USA
Darin Brown - Psychology Department, University of New Mexico, Albuquerque, NM, USA
James F Cavanagh - Psychology Department, University of New Mexico, Albuquerque, NM, USA
Nandakumar S Narayanan - Neurology Department, University of Iowa, Iowa City, IA, USA
Resource Type: Journal article
Publication Details: Clinical neurophysiology, Vol.131(3), pp.694-702
DOI: 10.1016/j.clinph.2019.12.399
PMID: 31991312
NLM abbreviation: Clin Neurophysiol
ISSN: 1388-2457
eISSN: 1872-8952
Publisher: Elsevier B.V
Grant note: DOI: 10.13039/100000065, name: NINDS, award: R01NS100849
Language: English
Date published: 03/2020
Academic Unit: Neurology; Iowa Neuroscience Institute
Record Identifier: 9984070213802771

Metrics

24 Record Views

87 Times Cited - Web of Science

See more details