Journal article
Frontoparietal network activation is associated with motor recovery in ischemic stroke patients
Communications biology, Vol.5(1), pp.993-993
09/21/2022
DOI: 10.1038/s42003-022-03950-4
PMCID: PMC9492673
PMID: 36131012
Abstract
Strokes cause lesions that damage brain tissue, disrupt normal brain activity patterns and can lead to impairments in motor function. Although modulation of cortical activity is central to stimulation-based rehabilitative therapies, aberrant and adaptive patterns of brain activity after stroke have not yet been fully characterized. Here, we apply a brain dynamics analysis approach to study longitudinal brain activity patterns in individuals with ischemic pontine stroke. We first found 4 commonly occurring brain states largely characterized by high amplitude activations in the visual, frontoparietal, default mode, and motor networks. Stroke subjects spent less time in the frontoparietal state compared to controls. For individuals with dominant-hand CST damage, more time spent in the frontoparietal state from 1 week to 3-6 months post-stroke was associated with better motor recovery over the same time period, an association which was independent of baseline impairment. Furthermore, the amount of time spent in brain states was linked empirically to functional connectivity. This work suggests that when the dominant-hand CST is compromised in stroke, resting state configurations may include increased activation of the frontoparietal network, which may facilitate compensatory neural pathways that support recovery of motor function when traditional motor circuits of the dominant-hemisphere are compromised.
Details
- Title: Subtitle
- Frontoparietal network activation is associated with motor recovery in ischemic stroke patients
- Creators
- Emily Olafson - Cornell CollegeGeorgia RusselloKeith W JamisonHesheng LiuDanhong WangJoel E BrussAaron D BoesAmy Kuceyeski
- Resource Type
- Journal article
- Publication Details
- Communications biology, Vol.5(1), pp.993-993
- DOI
- 10.1038/s42003-022-03950-4
- PMID
- 36131012
- PMCID
- PMC9492673
- NLM abbreviation
- Commun Biol
- eISSN
- 2399-3642
- Grant note
- DOI: 10.13039/100000065, name: U.S. Department of Health & Human Services | NIH | National Institute of Neurological Disorders and Stroke, award: R01 NS102646, R21 NS104634; DOI: 10.13039/100000025, name: U.S. Department of Health & Human Services | NIH | National Institute of Mental Health, award: RF1 MH123232; name: U.S. Department of Health & Human Services | NIH | National Institute of Neurological Disorders and Stroke; DOI: 10.13039/100000057, name: U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences, award: R21 NS120227-01
- Language
- English
- Date published
- 09/21/2022
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Neurology; Psychiatry; Stead Family Department of Pediatrics; Iowa Neuroscience Institute; Neurology (Pediatrics)
- Record Identifier
- 9984297660102771
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