Frontoparietal structural properties mediate adult life span differences in executive function

Zai-Fu Yao; Meng-Heng Yang; Kai Hwang; Shulan Hsieh

doi:10.1038/s41598-020-66083-w

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Frontoparietal structural properties mediate adult life span differences in executive function

Journal article

Open access

Peer reviewed

Frontoparietal structural properties mediate adult life span differences in executive function

Zai-Fu Yao, Meng-Heng Yang, Kai Hwang and Shulan Hsieh

Scientific reports, Vol.10(1), pp.9066-9066

06/03/2020

DOI: 10.1038/s41598-020-66083-w

PMID: 32494018

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https://doi.org/10.1038/s41598-020-66083-wView

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Abstract

Executive function (EF) refers to a set of cognitive functions that support goal-directed behaviors. Recent findings have suggested that the frontoparietal network (FPN) subserves neural processes that are related to EF. However, the FPN structural and functional network properties that mediate age-related differences in EF components remain unclear. To this end, we used three experimental tasks to test the component processes of EF based on Miyake and Friedman's model: one common EF component process (incorporating inhibition, shifting, and updating) and two specific EF component processes (shifting and updating). We recruited 126 healthy participants (65 females; 20 to 78 years old) who underwent both structural and functional MRI scanning. We tested a mediation path model of three structural and functional properties of the FPN (i.e., gray matter volume, white matter fractional anisotropy, and intra/internetwork functional connectivity) as mediators of age-related differences in the three EF components. The results indicated that age-related common EF component differences are mediated by regional gray matter volume changes in both hemispheres of the frontal lobe, which suggests that structural changes in the frontal lobe may have an indirect influence on age-related general elements of EF. These findings suggest that the FPN mediates age-related differences in specific components of EF.

Humans

Middle Aged

Magnetic Resonance Imaging - methods

Male

Brain Mapping - methods

Executive Function - physiology

Nerve Net - physiology

Frontal Lobe - physiology

Neuropsychological Tests

Young Adult

Anisotropy

Aged, 80 and over

Cognition - physiology

Adult

Female

Aged

White Matter - physiology

Gray Matter - physiology

Longevity - physiology

Details

Title: Subtitle: Frontoparietal structural properties mediate adult life span differences in executive function
Creators: Zai-Fu Yao - Brain and Cognition, Department of Psychology, University of Amsterdam, Amsterdam, The Netherlands
Meng-Heng Yang - Department of Psychology, National Cheng Kung University, Tainan, Taiwan
Kai Hwang - Iowa Neuroscience Institute, University of Iowa, Iowa, USA
Shulan Hsieh - Department and Institute of Public Health, National Cheng Kung University, Tainan, Taiwan. psyhsl@mail.ncku.edu.tw
Resource Type: Journal article
Publication Details: Scientific reports, Vol.10(1), pp.9066-9066
DOI: 10.1038/s41598-020-66083-w
PMID: 32494018
NLM abbreviation: Sci Rep
ISSN: 2045-2322
eISSN: 2045-2322
Publisher: England
Grant note: DOI: 10.13039/501100004663, name: Ministry of Science and Technology, Taiwan, award: MOST104-2410-H-006-021-MY2, MOST106-2410-H-006-031-MY2, MOST108-2410-H-006 -038 -MY3, MOST108-2321-B-006-022-MY2
Language: English
Date published: 06/03/2020
Academic Unit: Psychiatry; Psychological and Brain Sciences; Iowa Neuroscience Institute
Record Identifier: 9984066350502771

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