Fructose intolerance in IBS and utility of fructose-restricted diet

Young K Choi; Nancy Kraft; Bridget Zimmerman; Michelle Jackson; Satish S C Rao

doi:10.1097/MCG.0b013e31802cbc2f

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Fructose intolerance in IBS and utility of fructose-restricted diet

Journal article

Peer reviewed

Fructose intolerance in IBS and utility of fructose-restricted diet

Young K Choi, Nancy Kraft, Bridget Zimmerman, Michelle Jackson and Satish S C Rao

Journal of clinical gastroenterology, Vol.42(3), pp.233-238

03/2008

DOI: 10.1097/MCG.0b013e31802cbc2f

PMID: 18223504

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Abstract

Whether dietary fructose intolerance causes symptoms of irritable bowel syndrome (IBS) is unclear. We examined the prevalence of fructose intolerance in IBS and long-term outcome of fructose-restricted diet. Two hundred and nine patients with suspected IBS were retrospectively evaluated for organic illnesses. Patients with IBS (Rome II) and positive fructose breath test received instructions regarding fructose-restricted diet. One year later, their symptoms, compliance with, and effects of dietary modification on lifestyle were assessed using a structured interview. Eighty patients (m/f=26/54) fulfilled Rome II criteria. Of 80 patients, 31 (38%) had positive breath test. Of 31 patients, 26 (84%) participated in follow-up (mean=13 mo) evaluation. Of 26 patients, 14 (53%) were compliant with diet; mean compliance=71%. In this group, pain, belching, bloating, fullness, indigestion, and diarrhea improved (P<0.02). Of 26 patients, 12 (46%) were noncompliant, and their symptoms were unchanged, except belching. The mean impact on lifestyle, compliant versus noncompliant groups was 2.93 versus 2.57 (P>0.05). About one-third of patients with suspected IBS had fructose intolerance. When compliant, symptoms improved on fructose-restricted diet despite moderate impact on lifestyle; noncompliance was associated with persistent symptoms. Fructose intolerance is another jigsaw piece of the IBS puzzle that may respond to dietary modification.

Follow-Up Studies

Humans

Middle Aged

Breath Tests

Diet, Carbohydrate-Restricted - utilization

Male

Treatment Outcome

Inflammatory Bowel Diseases - diet therapy

Inflammatory Bowel Diseases - metabolism

Fructose - metabolism

Fructose Intolerance - diet therapy

Fructose Intolerance - etiology

Adult

Female

Surveys and Questionnaires

Aged

Fructose Intolerance - metabolism

Retrospective Studies

Inflammatory Bowel Diseases - complications

Details

Title: Subtitle: Fructose intolerance in IBS and utility of fructose-restricted diet
Creators: Young K Choi - Immanuel St Joseph's, Mayo Health System, Mankato, MN, USA
Nancy Kraft
Bridget Zimmerman
Michelle Jackson
Satish S C Rao
Resource Type: Journal article
Publication Details: Journal of clinical gastroenterology, Vol.42(3), pp.233-238
Publisher: United States
DOI: 10.1097/MCG.0b013e31802cbc2f
PMID: 18223504
ISSN: 0192-0790
eISSN: 1539-2031
Grant note: R01 DK 57100-05 / NIDDK NIH HHS RR00059 / NCRR NIH HHS
Language: English
Date published: 03/2008
Academic Unit: Biostatistics
Record Identifier: 9983997346602771

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