Journal article
Fruit, vegetables, fibre and micronutrients and risk of US renal cell carcinoma
British journal of nutrition, Vol.108(6), pp.1077-1085
09/28/2012
DOI: 10.1017/S0007114511006489
PMID: 22186835
Abstract
The association between renal cell cancer (RCC) and intake of fruit, vegetables and nutrients was examined in a population-based case–control study of 323 cases and 1827 controls; dietary intake was obtained using a mailed questionnaire. Cancer risks were estimated by OR and 95 % CI, adjusting for age, sex, smoking, obesity, hypertension, proxy status, alcohol consumption and dietary fat intake and energy. Intake of vegetables was associated with a decreased risk of RCC (OR 0·5; 95 % CI 0·3, 0·7; Ptrend = 0·002), (top compared to the bottom quartile of intake). When intake of individual nutrients was investigated, vegetable fibre intake was associated with decreased risks (OR 0·4; 95 % CI 0·2, 0·6; P < 0·001), but this was not the case with fruit fibre (OR 0·7; 95 % CI 0·4, 1·1) or grain fibre (OR 1·0; 95 % CI 0·6, 1·5). β-Cryptoxanthin and lycopene were also associated with decreased risks, but when both were included in a mutually adjusted backwards stepwise regression model, only β-cryptoxanthin remained significant (OR 0·5; 95 % CI 0·3, 0·8). When other micronutrients and types of fibre were investigated together, only vegetable fibre and β-cryptoxanthin had significant trends (P < 0·01) (OR 0·6; 95 % CI 0·3, 0·9) (OR 0·5; 95 % CI 0·3, 0·9), respectively. These findings were stronger in those aged over 65 years (Pinteraction = 0·001). Among non-smokers, low intake of cruciferous vegetables and fruit fibre was also associated with increased risk of RCC (Pinteraction = 0·03); similar inverse associations were found for β-cryptoxanthin, lycopene and vitamin C. When nutrients were mutually adjusted by backwards regression in these subgroups, only β-cryptoxanthin remained associated with lower RCC risk. These findings deserve further investigation in ongoing prospective studies when sample size becomes sufficient.
Details
- Title: Subtitle
- Fruit, vegetables, fibre and micronutrients and risk of US renal cell carcinoma
- Creators
- Kaye E Brock - 1Department of Behavioural and Social Sciences, Faculty of Health Sciences, University of Sydney, Sydney, New South Wales, AustraliaLiang Ke - 1Department of Behavioural and Social Sciences, Faculty of Health Sciences, University of Sydney, Sydney, New South Wales, AustraliaGloria Gridley - 2Department of Health and Human Services, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD, USABrian C.-H Chiu - 3Department of Health Studies, University of Chicago, Chicago, IL, USAAbby G Ershow - 4Department of Health and Human Services, National Heart, Lung and Blood Institute, NIH, Bethesda, MD, USACharles F Lynch - 5Department of Epidemiology, College of Public Health, University of Iowa, Iowa City, IA, USABarry I Graubard - 2Department of Health and Human Services, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD, USAKenneth P Cantor - 2Department of Health and Human Services, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD, USA
- Resource Type
- Journal article
- Publication Details
- British journal of nutrition, Vol.108(6), pp.1077-1085
- Publisher
- Cambridge University Press; Cambridge, UK
- DOI
- 10.1017/S0007114511006489
- PMID
- 22186835
- ISSN
- 0007-1145
- eISSN
- 1475-2662
- Number of pages
- 9
- Alternative title
- Fibre-rich foods and risk of US kidney cancer
- Language
- English
- Date published
- 09/28/2012
- Academic Unit
- Epidemiology
- Record Identifier
- 9983995039202771
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