Fuchs Endothelial Corneal Dystrophy: A Post Hoc Analysis of the Women’s Health Initiative Randomized Hormone Therapy Clinical Trials

Amy E. Millen; Jing Nie; Jean Wactawski-Wende; Chris A. Andrews; Aladdin H. Shadyab; Robert B. Wallace; Sangita P. Patel; Women’s Health Initiative Investigators

doi:10.1001/jamaophthalmol.2025.6340

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Fuchs Endothelial Corneal Dystrophy: A Post Hoc Analysis of the Women’s Health Initiative Randomized Hormone Therapy Clinical Trials

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Fuchs Endothelial Corneal Dystrophy: A Post Hoc Analysis of the Women’s Health Initiative Randomized Hormone Therapy Clinical Trials

Amy E. Millen, Jing Nie, Jean Wactawski-Wende, Chris A. Andrews, Aladdin H. Shadyab, Robert B. Wallace, Sangita P. Patel and Women’s Health Initiative Investigators

JAMA ophthalmology

02/19/2026

DOI: 10.1001/jamaophthalmol.2025.6340

PMCID: PMC12921561

PMID: 41712224

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https://pmc.ncbi.nlm.nih.gov/articles/PMC12921561/View

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Abstract

This post hoc secondary analysis of the Women’s Health Initiative study assesses whether randomization to hormone therapy use was associated with subsequent incident Fuchs endothelial corneal dystrophy.

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Title: Subtitle: Fuchs Endothelial Corneal Dystrophy: A Post Hoc Analysis of the Women’s Health Initiative Randomized Hormone Therapy Clinical Trials
Creators: Amy E. Millen - University at Buffalo, State University of New York
Jing Nie - University at Buffalo, State University of New York
Jean Wactawski-Wende - University at Buffalo, State University of New York
Chris A. Andrews - University of Michigan
Aladdin H. Shadyab - University of California San Diego
Robert B. Wallace - University of Iowa
Sangita P. Patel - VA Western New York Healthcare System
Women’s Health Initiative Investigators
Resource Type: Journal article
Publication Details: JAMA ophthalmology
DOI: 10.1001/jamaophthalmol.2025.6340
PMID: 41712224
PMCID: PMC12921561
NLM abbreviation: JAMA Ophthalmol
ISSN: 2168-6165
eISSN: 2168-6173
Publisher: American Medical Association
Grant note: National Institutes of Health - National Heart, Lung, and Blood Institute, National Institutes of Health, US Department of Health and Human Services: R21 EY032544-01, K08 EY029007 Veterans Affairs Western New York Healthcare System, Buffalo: 75N92021D00001, 75N92021D00002, 75N92021D00003, 75N92021D00004, 75N92021D00005
This study was supported by grants R21 EY032544-01 (Dr Millen) and K08 EY029007 (Dr Patel) from the National Institutes of Health. The Women's Health Initiative program is funded by the National Heart, Lung, and Blood Institute, National Institutes of Health, US Department of Health and Human Services, through contracts 75N92021D00001, 75N92021D00002, 75N92021D00003, 75N92021D00004, and 75N92021D00005. This material is the result of work supported with resources and the use of facilities at the Veterans Affairs Western New York Healthcare System, Buffalo.
Alternative title: Fuchs Endothelial Corneal Dystrophy
Language: English
Electronic publication date: 02/19/2026
Academic Unit: Epidemiology; Injury Prevention Research Center
Record Identifier: 9985139302402771

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