Journal article
Fueling the cytoskeleton - links between cell metabolism and actin remodeling
Journal of cell science, Vol.134(3), jcs248385
02/01/2021
DOI: 10.1242/jcs.248385
PMCID: PMC7888749
PMID: 33558441
Abstract
Attention has long focused on the actin cytoskeleton as a unit capable of organizing into ensembles that control cell shape, polarity, migration and the establishment of intercellular contacts that support tissue architecture. However, these investigations do not consider observations made over 40 years ago that the actin cytoskeleton directly binds metabolic enzymes, or emerging evidence suggesting that the rearrangement and assembly of the actin cytoskeleton is a major energetic drain. This Review examines recent studies probing how cells adjust their metabolism to provide the energy necessary for cytoskeletal remodeling that occurs during cell migration, epithelial to mesenchymal transitions, and the cellular response to external forces. These studies have revealed that mechanotransduction, cell migration, and epithelial to mesenchymal transitions are accompanied by alterations in glycolysis and oxidative phosphorylation. These metabolic changes provide energy to support the actin cytoskeletal rearrangements necessary to allow cells to assemble the branched actin networks required for cell movement and epithelial to mesenchymal transitions and the large actin bundles necessary for cells to withstand forces. In this Review, we discuss the emerging evidence suggesting that the regulation of these events is highly complex with metabolism affecting the actin cytoskeleton and vice versa.
Details
- Title: Subtitle
- Fueling the cytoskeleton - links between cell metabolism and actin remodeling
- Creators
- Gillian DeWane - Roy J. and Lucille A. Carver College of MedicineAlicia M. Salvi - Roy J. and Lucille A. Carver College of MedicineKris A. DeMali - Roy J. and Lucille A. Carver College of Medicine
- Resource Type
- Journal article
- Publication Details
- Journal of cell science, Vol.134(3), jcs248385
- Publisher
- Company Biologists Ltd
- DOI
- 10.1242/jcs.248385
- PMID
- 33558441
- PMCID
- PMC7888749
- ISSN
- 0021-9533
- eISSN
- 1477-9137
- Number of pages
- 10
- Grant note
- R35GM136291; F31GM135962 / National Institutes of Health (NIH); United States Department of Health & Human Services; National Institutes of Health (NIH) - USA
- Language
- English
- Date published
- 02/01/2021
- Academic Unit
- Dermatology; Pathology; Fraternal Order of Eagles Diabetes Research Center; Biochemistry and Molecular Biology
- Record Identifier
- 9984288728502771
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