Journal article
Function and Modulation of Type I Interferons during Respiratory Syncytial Virus Infection
Vaccines (Basel), Vol.8(2), p.177
06/01/2020
DOI: 10.3390/vaccines8020177
PMCID: PMC7349809
PMID: 32290326
Abstract
Respiratory syncytial virus (RSV) is the leading cause of lower respiratory infections in infants and young children, accounting for an estimated 3 million hospitalizations annually worldwide. Despite the major health burden, there is currently no licensed RSV vaccine. RSV is recognized by a range of cellular receptors including both toll-like receptors (TLR) and retinoic acid-inducible gene-I-like receptors (RIG-I). This interaction initiates signaling through mitochondrial antiviral signaling (MAVS) and interferon regulatory factor (IRF) proteins, resulting in the induction of type I interferons (IFN). Early viral control is mediated by either IFN-alpha or IFN-beta signaling through the IFN receptor (IFNAR), inducing the production of antiviral interferon-stimulating genes (ISGs). Type I IFNs also initiate the early production of proinflammatory cytokines including interleukin 6 (IL-6), tumor necrosis factor (TNF), and IFN-gamma. Type I IFN levels correlate with age, and inadequate production may be a critical factor in facilitating the increased RSV disease severity observed in infants. Here, we review the current literature on the function of type I IFNs in RSV pathogenesis, as well as their involvement in the differential immune responses observed in infants and adults.
Details
- Title: Subtitle
- Function and Modulation of Type I Interferons during Respiratory Syncytial Virus Infection
- Creators
- Laura M. Stephens - University of IowaSteven M. Varga - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Vaccines (Basel), Vol.8(2), p.177
- DOI
- 10.3390/vaccines8020177
- PMID
- 32290326
- PMCID
- PMC7349809
- NLM abbreviation
- Vaccines (Basel)
- ISSN
- 2076-393X
- eISSN
- 2076-393X
- Publisher
- Mdpi
- Number of pages
- 16
- Grant note
- R01AI124093; T32AI007485 / National Institute of Allergy and Infectious Diseases of the National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Allergy & Infectious Diseases (NIAID)
- Language
- English
- Date published
- 06/01/2020
- Academic Unit
- Graduate College Admin and Gen; Microbiology and Immunology; Pathology
- Record Identifier
- 9984297320202771
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