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Function of Cryopreserved Mesenchymal Stromal Cells With and Without Interferon-γ Prelicensing is Context Dependent
Journal article   Peer reviewed

Function of Cryopreserved Mesenchymal Stromal Cells With and Without Interferon-γ Prelicensing is Context Dependent

Anthony J Burand, Oliver W Gramlich, Alex J Brown and James A Ankrum
Stem cells (Dayton, Ohio), Vol.35(5), pp.1437-1439
05/2017
DOI: 10.1002/stem.2528
PMCID: PMC5397371
PMID: 27758056

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Abstract

Tailoring MSCs to fit the disease. Fresh, cryopreserved and, prelicensed cryopreserved MSC are all being explored to treat numerous diseases, but all are not suitable to treat all conditions. injury. "*" denotes preferred therapeutic strategy when both fresh MSC and cryo-MSC have shown utility in treating the disease but one is more efficacious or logistically suitable. CLI, critical limb ischemia; GvHD. graft versus host disease; I/R, ischemia reperfusion (I/R); OI, osteogenesis imperfecta.
Indoleamine-Pyrrole 2,3,-Dioxygenase - metabolism Mesenchymal Stromal Cells - drug effects Mesenchymal Stromal Cells - cytology Animals Reperfusion Injury - pathology Cryopreservation Humans Mice, Inbred C57BL Interferon-gamma - pharmacology

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