Functional Impacts of Epitranscriptomic m6A Modification on HIV-1 Infection

Stacia Phillips; Tarun Mishra; Siyu Huang; Li Wu

doi:10.3390/v16010127

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Functional Impacts of Epitranscriptomic m6A Modification on HIV-1 Infection

Journal article

Open access

Peer reviewed

Functional Impacts of Epitranscriptomic m6A Modification on HIV-1 Infection

Stacia Phillips, Tarun Mishra, Siyu Huang and Li Wu

Viruses, Vol.16(1), 127

01/16/2024

DOI: 10.3390/v16010127

PMCID: PMC10820791

PMID: 38257827

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Abstract

Epitranscriptomic RNA modifications play a crucial role in the posttranscriptional regulation of gene expression. N6-methyladenosine (m6A) is the most prevalent internal modification of eukaryotic RNA and plays a pivotal role in RNA fate. RNA m6A modification is regulated by a group of cellular proteins, methyltransferases (writers) and demethylases (erasers), which add and remove the methyl group from adenosine, respectively. m6A modification is recognized by a group of cellular RNA-binding proteins (readers) that specifically bind to m6A-modified RNA, mediating effects on RNA stability, splicing, transport, and translation. The functional significance of m6A modification of viral and cellular RNA is an active area of virology research. In this review, we summarize and analyze the current literature on m6A modification of HIV-1 RNA, the multifaceted functions of m6A in regulating HIV-1 replication, and the role of viral RNA m6A modification in evading innate immune responses to infection. Furthermore, we briefly discuss the future directions and therapeutic implications of mechanistic studies of HIV-1 epitranscriptomic modifications.

Details

Title: Subtitle: Functional Impacts of Epitranscriptomic m6A Modification on HIV-1 Infection
Creators: Stacia Phillips - University of Iowa
Tarun Mishra - University of Iowa
Siyu Huang - University of Iowa
Li Wu - University of Iowa
Resource Type: Journal article
Publication Details: Viruses, Vol.16(1), 127
DOI: 10.3390/v16010127
PMID: 38257827
PMCID: PMC10820791
NLM abbreviation: Viruses
ISSN: 1999-4915
eISSN: 1999-4915
Grant note: name: National Institutes of Health (NIH) of the USA, award: AI169659, AI170070, AI159546
Language: English
Date published: 01/16/2024
Academic Unit: Microbiology and Immunology
Record Identifier: 9984548407702771

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