Functional MRI detection of hemodynamic response of repeated median nerve stimulation

Leo Ai; Hiroyuki Oya; Matthew Howard; Jinhu Xiong

doi:10.1016/j.mri.2012.10.012

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Functional MRI detection of hemodynamic response of repeated median nerve stimulation

Journal article

Open access

Peer reviewed

Functional MRI detection of hemodynamic response of repeated median nerve stimulation

Leo Ai, Hiroyuki Oya, Matthew Howard and Jinhu Xiong

Magnetic resonance imaging, Vol.31(4), pp.550-554

05/2013

DOI: 10.1016/j.mri.2012.10.012

PMCID: PMC3610813

PMID: 23228312

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https://www.ncbi.nlm.nih.gov/pmc/articles/3610813View

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Abstract

Median nerve stimulation is a commonly used technique in the clinical setting to determine areas of neuronal function in the brain. Neuronal activity of repeated median nerve stimulation is well studied. The cerebral hemodynamic response of the stimulation, on the other hand, is not very clear. In this study, we investigate how cerebral hemodynamics behave over time using the same repeated median nerve stimulation. Ten subjects received constant repeated electrical stimulation to the right median nerve. Each subject had functional magnetic resonance imaging scans while receiving said stimulations for seven runs. Our results show that the blood oxygen level-dependent (BOLD) signal significantly decreases across each run. Significant BOLD signal decreases can also be seen within runs. These results are consistent with studies that have studied the hemodynamic habituation effect with other forms of stimulation. However, the results do not completely agree with the findings of studies where evoked potentials were examined. Thus, further inquiry of how evoked potentials and cerebral hemodynamics are coupled when using constant stimulations is needed.

Median Nerve - physiology

Cerebrovascular Circulation - physiology

Humans

Magnetic Resonance Imaging - methods

Evoked Potentials - physiology

Male

Brain Mapping - methods

Brain - physiology

Electrodiagnosis - methods

Young Adult

Habituation, Psychophysiologic - physiology

Adult

Female

Electric Stimulation - methods

Details

Title: Subtitle: Functional MRI detection of hemodynamic response of repeated median nerve stimulation
Creators: Leo Ai - Department of Biomedical Engineering, University of Iowa, 200 Hawkins Drive, C721 GH, Iowa City, IA 52242, USA. leo-ai@uiowa.edu
Hiroyuki Oya
Matthew Howard
Jinhu Xiong
Resource Type: Journal article
Publication Details: Magnetic resonance imaging, Vol.31(4), pp.550-554
DOI: 10.1016/j.mri.2012.10.012
PMID: 23228312
PMCID: PMC3610813
NLM abbreviation: Magn Reson Imaging
ISSN: 0730-725X
eISSN: 1873-5894
Publisher: Netherlands
Grant note: R01 DC004290 / NIDCD NIH HHS R01 DC004290-11 / NIDCD NIH HHS R21 MH 082187-01 / NIMH NIH HHS R21 MH082187 / NIMH NIH HHS
Language: English
Date published: 05/2013
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Neurology; Iowa Neuroscience Institute; Neurosurgery; Otolaryngology
Record Identifier: 9984040017502771

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