Journal article
Functional Segregation of Cortical Regions Underlying Speech Timing and Articulation
Neuron (Cambridge, Mass.), Vol.89(6), pp.1187-1193
03/16/2016
DOI: 10.1016/j.neuron.2016.01.032
PMCID: PMC4833207
PMID: 26924439
Abstract
Spoken language is a central part of our everyday lives, but the precise roles that individual cortical regions play in the production of speech are often poorly understood. To address this issue, we focally lowered the temperature of distinct cortical regions in awake neurosurgical patients, and we relate this perturbation to changes in produced speech sequences. Using this method, we confirm that speech is highly lateralized, with the vast majority of behavioral effects seen on the left hemisphere. We then use this approach to demonstrate a clear functional dissociation between nearby cortical speech sites. Focal cooling of pars triangularis/pars opercularis (Broca's region) and the ventral portion of the precentral gyrus (speech motor cortex) resulted in the manipulation of speech timing and articulation, respectively. Our results support a class of models that have proposed distinct processing centers underlying motor sequencing and execution for speech.
Details
- Title: Subtitle
- Functional Segregation of Cortical Regions Underlying Speech Timing and Articulation
- Creators
- Michael A Long - NYU Neuroscience Institute, Department of Otolaryngology, NYU Neuroscience Institute, New York University Langone Medical Center, New York, NY 10016 USA; Center for Neural Science, New York University, New York, NY 10003 USA. Electronic address: mlong@med.nyu.eduKalman A Katlowitz - NYU Neuroscience Institute, Department of Otolaryngology, NYU Neuroscience Institute, New York University Langone Medical Center, New York, NY 10016 USA; Center for Neural Science, New York University, New York, NY 10003 USAMario A Svirsky - NYU Neuroscience Institute, Department of Otolaryngology, NYU Neuroscience Institute, New York University Langone Medical Center, New York, NY 10016 USA; Center for Neural Science, New York University, New York, NY 10003 USARachel C Clary - NYU Neuroscience Institute, Department of Otolaryngology, NYU Neuroscience Institute, New York University Langone Medical Center, New York, NY 10016 USA; Center for Neural Science, New York University, New York, NY 10003 USATara McAllister Byun - Department of Communicative Sciences and Disorders, New York University, New York, NY 10012 USANajib Majaj - Center for Neural Science, New York University, New York, NY 10003 USAHiroyuki Oya - Department of Neurosurgery, Human Brain Research Lab, University of Iowa, Iowa City, IA 52242 USAMatthew A Howard III - Department of Neurosurgery, Human Brain Research Lab, University of Iowa, Iowa City, IA 52242 USAJeremy D W Greenlee - Department of Neurosurgery, Human Brain Research Lab, University of Iowa, Iowa City, IA 52242 USA
- Resource Type
- Journal article
- Publication Details
- Neuron (Cambridge, Mass.), Vol.89(6), pp.1187-1193
- Publisher
- United States
- DOI
- 10.1016/j.neuron.2016.01.032
- PMID
- 26924439
- PMCID
- PMC4833207
- ISSN
- 0896-6273
- eISSN
- 1097-4199
- Grant note
- R01 DC004290 / NIDCD NIH HHS DC004290 / NIDCD NIH HHS NS075044 / NINDS NIH HHS R01 NS075044 / NINDS NIH HHS DC009589 / NIDCD NIH HHS K23 DC009589 / NIDCD NIH HHS
- Language
- English
- Date published
- 03/16/2016
- Academic Unit
- Neurology; Stead Family Department of Pediatrics; Iowa Neuroscience Institute; Neurosurgery; Otolaryngology
- Record Identifier
- 9984020797402771
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