Journal article
Functional Synthetic Biology
Synthetic biology (Oxford University Press), Vol.8(1), pp.ysad006-ysad006
2023
DOI: 10.1093/synbio/ysad006
PMCID: PMC10105873
PMID: 37073284
Abstract
Synthetic biologists have made great progress over the past decade in developing methods for modular assembly of genetic sequences and in engineering biological systems with a wide variety of functions in various contexts and organisms. However, current paradigms in the field entangle sequence and functionality in a manner that makes abstraction difficult, reduces engineering flexibility and impairs predictability and design reuse. Functional Synthetic Biology aims to overcome these impediments by focusing the design of biological systems on function, rather than on sequence. This reorientation will decouple the engineering of biological devices from the specifics of how those devices are put to use, requiring both conceptual and organizational change, as well as supporting software tooling. Realizing this vision of Functional Synthetic Biology will allow more flexibility in how devices are used, more opportunity for reuse of devices and data, improvements in predictability and reductions in technical risk and cost.
Details
- Title: Subtitle
- Functional Synthetic Biology
- Creators
- Ibrahim Aldulijan - Stevens Institute of TechnologyJacob Beal - RTXSonja Billerbeck - University of GroningenJeff Bouffard - Concordia UniversityGael Chambonnier - Massachusetts Institute of TechnologyNikolaos Ntelkis - VIB-UGent Center for Plant Systems BiologyIsaac Guerreiro - International Genetically Engineered Machine FoundationMartin Holub - Delft University of TechnologyPaul Ross - CircleVinoo Selvarajah - International Genetically Engineered Machine FoundationNoah Sprent - Imperial College LondonGonzalo Vidal - Newcastle UniversityAlejandro Vignoni - Universitat Politècnica de València
- Resource Type
- Journal article
- Publication Details
- Synthetic biology (Oxford University Press), Vol.8(1), pp.ysad006-ysad006
- Publisher
- Oxford Univ Press
- DOI
- 10.1093/synbio/ysad006
- PMID
- 37073284
- PMCID
- PMC10105873
- ISSN
- 1939-7267
- eISSN
- 2397-7000
- Number of pages
- 8
- Grant note
- FA8750-17-C-0184 / Air Force Research Laboratory and Defense Advanced Research Projects Agency (DARPA) School of Computing, Newcastle University Horizon Postdoctoral Fellowship from Concordia University 883684 / European Research Council (ERC) Advanced Grant LoopingDNA; European Research Council (ERC) DPI2017-82896-C2-1-R / MINECO/AEI, EU PID2020-117271RB-C21 / MCIN/AEI BB/M011178/1 / Biotechnology and Biological Sciences Research Council (BBSRC); UK Research & Innovation (UKRI)
- Language
- English
- Date published
- 2023
- Academic Unit
- Electrical and Computer Engineering
- Record Identifier
- 9984627285202771
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