Journal article
Functional Variant in a Bitter-Taste Receptor ( hTAS2R16) Influences Risk of Alcohol Dependence
American journal of human genetics, Vol.78(1), pp.103-111
2006
DOI: 10.1086/499253
PMCID: PMC1380207
PMID: 16385453
Abstract
A coding single-nucleotide polymorphism (cSNP),
K172N, in
hTAS2R16, a gene encoding a taste receptor for bitter β-glucopyranosides, shows significant association with alcohol dependence (
P=
.00018). This gene is located on chromosome 7q in a region reported elsewhere to exhibit linkage with alcohol dependence. The SNP is located in the putative ligand-binding domain and is associated with an increased sensitivity to many bitter β-glucopyranosides in the presence of the N172 allele. Individuals with the ancestral allele K172 are at increased risk of alcohol dependence, regardless of ethnicity. However, this risk allele is uncommon in European Americans (minor-allele frequency [MAF] 0.6%), whereas 45% of African Americans carry the allele (MAF 26%), which makes it a much more significant risk factor in the African American population.
Details
- Title: Subtitle
- Functional Variant in a Bitter-Taste Receptor ( hTAS2R16) Influences Risk of Alcohol Dependence
- Creators
- Anthony L. Hinrichs - Washington University in St. LouisJen C. Wang - Washington University in St. LouisBernd Bufe - German Institute of Human NutritionJennifer M. Kwon - Washington University in St. LouisJohn Budde - Washington University in St. LouisRebecca Allen - Washington University in St. LouisSarah Bertelsen - Washington University in St. LouisWhitney Evans - National Institutes of HealthDanielle Dick - Washington University in St. LouisJohn Rice - Washington University in St. LouisTatiana Foroud - University of IndianapolisJohn Nurnberger - University of IndianapolisJay A. Tischfield - Rutgers, The State University of New JerseySamuel Kuperman - Rutgers, The State University of New JerseyRaymond Crowe - University of IowaVictor Hesselbrock - University of ConnecticutMarc Schuckit - University of California San DiegoLaura Almasy - Texas Biomedical Research InstituteBernice Porjesz - SUNY Downstate Health Sciences UniversityHoward J. Edenberg - University of IndianapolisHenri Begleiter - SUNY Downstate Health Sciences UniversityWolfgang Meyerhof - German Institute of Human NutritionLaura J. Bierut - Washington University in St. LouisAlison M. Goate - Washington University in St. Louis
- Resource Type
- Journal article
- Publication Details
- American journal of human genetics, Vol.78(1), pp.103-111
- DOI
- 10.1086/499253
- PMID
- 16385453
- PMCID
- PMC1380207
- NLM abbreviation
- Am J Hum Genet
- ISSN
- 0002-9297
- eISSN
- 1537-6605
- Publisher
- Elsevier Inc
- Language
- English
- Date published
- 2006
- Academic Unit
- Psychiatry
- Record Identifier
- 9984293653802771
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