Functional abnormalities in the neural circuitry of reading in men with nonsyndromic clefts of the lip or palate

Grant Goldsberry; Dan O'Leary; Rich Hichwa; Peg Nopoulos

doi:10.1597/05-043

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Functional abnormalities in the neural circuitry of reading in men with nonsyndromic clefts of the lip or palate

Journal article

Peer reviewed

Functional abnormalities in the neural circuitry of reading in men with nonsyndromic clefts of the lip or palate

Grant Goldsberry, Dan O'Leary, Rich Hichwa and Peg Nopoulos

The Cleft palate-craniofacial journal, Vol.43(6), pp.683-690

11/2006

DOI: 10.1597/05-043

PMID: 17105320

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Abstract

The current study was designed to evaluate the neurobiology of reading in a group of men with nonsyndromic clefts of the lip or palate (NSCLP) compared with healthy controls by positron emission tomography. SUBJECTS included eight men with NSCLP compared with six healthy control men. By using radioactively labeled water (O(15)), regional brain blood flow was obtained during the performance of three simple reading tasks: reading unrelated words, reading unrelated sentences, and reading a story. During each of the reading conditions, NSCLP subjects compared with healthy controls showed increased blood flow in areas previously reported to be involved in language processing and reading (inferior frontal lobe, cerebellum, and occipital lobe). The increased blood flow suggests a possible neural inefficiency. In contrast, when analyzing the brain regions involved in more complex language functioning (reading stories compared with reading only words), control subjects showed an increase in blood flow in a distributed neural circuit, whereas the NSCLP subjects showed a decrease in flow in these regions. Additionally, the NSCLP subjects had activation of several regions not activated in the healthy controls, suggesting a compensatory circuit used for this more complex reading task. These results indicate that subjects with NSCLP show abnormalities in the function of the distributed neural circuitry used for oral reading.

Language Arts

Neurobiology

Brain - diagnostic imaging

Oxygen Radioisotopes

Cerebrovascular Circulation - physiology

Brain - physiopathology

Frontal Lobe - physiopathology

Humans

Male

Cerebellum - physiopathology

Cleft Palate - physiopathology

Positron-Emission Tomography

Image Processing, Computer-Assisted - methods

Occipital Lobe - physiopathology

Frontal Lobe - diagnostic imaging

Reading

Cerebellum - diagnostic imaging

Cleft Lip - physiopathology

Cognition - physiology

Adult

Radiopharmaceuticals

Occipital Lobe - diagnostic imaging

Details

Title: Subtitle: Functional abnormalities in the neural circuitry of reading in men with nonsyndromic clefts of the lip or palate
Creators: Grant Goldsberry - Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
Dan O'Leary
Rich Hichwa
Peg Nopoulos
Resource Type: Journal article
Publication Details: The Cleft palate-craniofacial journal, Vol.43(6), pp.683-690
DOI: 10.1597/05-043
PMID: 17105320
NLM abbreviation: Cleft Palate Craniofac J
ISSN: 1055-6656
eISSN: 1545-1569
Publisher: United States
Language: English
Date published: 11/2006
Academic Unit: Neurology; Radiology; Psychiatry; Research Administration; Stead Family Department of Pediatrics; Iowa Neuroscience Institute; Physics and Astronomy; Radiation Oncology
Record Identifier: 9984003926902771

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