Journal article
Functional and structural vascular responses to increased blood pressure variability is frequency dependent
The FASEB journal, Vol.25, pp.818.9-818.9
04/2011
DOI: 10.1096/fasebj.25.1_supplement.818.9
Abstract
Increased very low frequency (VLF) blood pressure variability (BPV), secondary to impaired baroreflex function, leads to vascular hypertrophy even without hypertension. We tested the hypothesis the BPV‐induced vascular damage depends on the pattern of BPV, such that VLF BPV is more detrimental than low (LF) BPV. VLF (30s period) or LF (3s period) BPV was induced in normotensive rats by computer‐controlled telemetric cardiac pacing. During a pacing period of 3 weeks, structural and functional parameters of the long posterior ciliary artery (LPCA) of the iris were assessed using a novel and innovative in vivo imaging technique using a slit lamp biomicroscope. Preliminary data of this ongoing study demonstrate that after 3 weeks wall to lumen ratio was increased by 17.2±11.7% (n=5) in rats exposed to VLF BPV, by 8.3±10.9% (n=4) in rats exposed to LF BPV, and by 2.1±7.8% (n=5) in control rats. Endothelial‐mediated dilation of the LPCA in response to corneal application of pilocarpine was abolished in 2 of 3 rats exposed to VLF BPV (Δ lumen diameter: 10.1±10.3%), while both rats exposed to LF BPV had preserved endothelial function (Δ lumen diameter: 52.6±2.0%). The greater impact of VLF BPV compared to LF BPV on endothelial function, suggests that increased VLF BPV in patients with impaired baroreflex function (e.g., diabetes or hypertension) may contribute to their overall increased cardiovascular risk. Supported by the AHA.
Details
- Title: Subtitle
- Functional and structural vascular responses to increased blood pressure variability is frequency dependent
- Creators
- Kevin R RarickDarin J LarsonDiane L RotellaMichael G Anderson - The University of IowaHarald M Stauss
- Resource Type
- Journal article
- Publication Details
- The FASEB journal, Vol.25, pp.818.9-818.9
- Publisher
- Federation of American Societies for Experimental Biology
- DOI
- 10.1096/fasebj.25.1_supplement.818.9
- ISSN
- 0892-6638
- eISSN
- 1530-6860
- Number of pages
- 1
- Grant note
- AHA
- Language
- English
- Date published
- 04/2011
- Academic Unit
- Health and Human Physiology; Molecular Physiology and Biophysics; Ophthalmology and Visual Sciences
- Record Identifier
- 9984172168702771
Metrics
8 Record Views