Functional brain architecture is associated with the rate of tau accumulation in Alzheimer’s disease

Nicolai Franzmeier; Julia Neitzel; Anna Rubinski; Ruben Smith; Olof Strandberg; Rik Ossenkoppele; Oskar Hansson; Michael Ewers; Alzheimer’s Disease Neuroimaging Initiative (ADNI)

doi:10.1038/s41467-019-14159-1

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Functional brain architecture is associated with the rate of tau accumulation in Alzheimer’s disease

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Functional brain architecture is associated with the rate of tau accumulation in Alzheimer’s disease

Nicolai Franzmeier, Julia Neitzel, Anna Rubinski, Ruben Smith, Olof Strandberg, Rik Ossenkoppele, Oskar Hansson, Michael Ewers and Alzheimer’s Disease Neuroimaging Initiative (ADNI)

Nature communications, Vol.11(1), pp.347-347

01/17/2020

DOI: 10.1038/s41467-019-14159-1

PMCID: PMC6969065

PMID: 31953405

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Abstract

In Alzheimer’s diseases (AD), tau pathology is strongly associated with cognitive decline. Preclinical evidence suggests that tau spreads across connected neurons in an activity-dependent manner. Supporting this, cross-sectional AD studies show that tau deposition patterns resemble functional brain networks. However, whether higher functional connectivity is associated with higher rates of tau accumulation is unclear. Here, we combine resting-state fMRI with longitudinal tau-PET in two independent samples including 53 (ADNI) and 41 (BioFINDER) amyloid-biomarker defined AD subjects and 28 (ADNI) vs. 16 (BioFINDER) amyloid-negative healthy controls. In both samples, AD subjects show faster tau accumulation than controls. Second, in AD, higher fMRI-assessed connectivity between 400 regions of interest (ROIs) is associated with correlated tau-PET accumulation in corresponding ROIs. Third, we show that a model including baseline connectivity and tau-PET is associated with future tau-PET accumulation. Together, connectivity is associated with tau spread in AD, supporting the view of transneuronal tau propagation. Tau accumulation is associated with disease progression in Alzheimer’s disease. Here the authors use resting state fMRI and tau-PET to demonstrate that baseline connectivity in Alzheimer's disease is associated with tau spreading.

Neurodegenerative Diseases

Neuroscience

Alzheimer's disease

Details

Title: Subtitle: Functional brain architecture is associated with the rate of tau accumulation in Alzheimer’s disease
Creators: Nicolai Franzmeier - Munich, Germany
Julia Neitzel - Munich, Germany
Anna Rubinski - Munich, Germany
Ruben Smith - Lund, Sweden Lund, Sweden
Olof Strandberg - Lund, Sweden
Rik Ossenkoppele - Lund, Sweden Amsterdam, the Netherlands
Oskar Hansson - Lund, Sweden Malmo, Sweden
Michael Ewers - Munich, Germany
Alzheimer’s Disease Neuroimaging Initiative (ADNI)
Contributors: HyungSub Shim (Contributor) - University of Iowa, Neurology
Resource Type: Journal article
Publication Details: Nature communications, Vol.11(1), pp.347-347
DOI: 10.1038/s41467-019-14159-1
PMID: 31953405
PMCID: PMC6969065
NLM abbreviation: Nat Commun
ISSN: 2041-1723
eISSN: 2041-1723
Publisher: Nature Publishing Group UK
Language: English
Date published: 01/17/2020
Academic Unit: Neurology; Psychiatry
Record Identifier: 9984303011702771

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