Functional connections between auditory cortex on Heschl's gyrus and on the lateral superior temporal gyrus in humans

John F Brugge; Igor O Volkov; P Charles Garell; Richard A Reale; Matthew A Howard III

doi:10.1152/jn.00500.2003

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Functional connections between auditory cortex on Heschl's gyrus and on the lateral superior temporal gyrus in humans

Journal article

Peer reviewed

Functional connections between auditory cortex on Heschl's gyrus and on the lateral superior temporal gyrus in humans

John F Brugge, Igor O Volkov, P Charles Garell, Richard A Reale and Matthew A Howard III

Journal of neurophysiology, Vol.90(6), pp.3750-3763

12/2003

DOI: 10.1152/jn.00500.2003

PMID: 12968011

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Abstract

Functional connections between auditory fields on Heschl's gyrus (HG) and the acoustically responsive posterior lateral superior temporal gyrus (field PLST) were studied using electrical stimulation and recording methods in patients undergoing diagnosis and treatment of intractable epilepsy. Averaged auditory (click-train) evoked potentials were recorded from multicontact subdural recording arrays chronically implanted over the lateral surface of the superior temporal gyrus (STG) and from modified depth electrodes inserted into HG. Biphasic electrical pulses (bipolar, constant current, 0.2 ms) were delivered to HG sites while recording from the electrode array over acoustically responsive STG cortex. Stimulation of sites along the mediolateral extent of HG resulted in complex waveforms distributed over posterolateral STG. These areas overlapped each other and field PLST. For any given HG stimulus site, the morphology of the electrically evoked waveform varied across the STG map. A characteristic waveform was recorded at the site of maximal amplitude of response to stimulation of mesial HG [presumed primary auditory field (AI)]. Latency measurements suggest that the earliest evoked wave resulted from activation of connections within the cortex. Waveforms changed with changes in rate of electrical HG stimulation or with shifts in the HG stimulus site. Data suggest widespread convergence and divergence of input from HG to posterior STG. Evidence is presented for a reciprocal functional projection, from posterolateral STG to HG. Results indicate that in humans there is a processing stream from AI on mesial HG to an associational auditory field (PLST) on the lateral surface of the superior temporal gyrus.

Electrophysiology

Electroencephalography

Electric Stimulation

Acoustic Stimulation

Humans

Middle Aged

Epilepsy - surgery

Male

Prosencephalon - physiology

Auditory Cortex - physiology

Auditory Perception - physiology

Electrodes

Neurosurgical Procedures

Auditory Pathways - physiology

Evoked Potentials, Auditory - physiology

Adult

Female

Temporal Lobe - physiology

Details

Title: Subtitle: Functional connections between auditory cortex on Heschl's gyrus and on the lateral superior temporal gyrus in humans
Creators: John F Brugge - Department of Neurosurgery, University of Iowa College of Medicine, Iowa City, Iowa 52242, USA. brugge@waisman.wisc.edu
Igor O Volkov
P Charles Garell
Richard A Reale
Matthew A Howard III
Resource Type: Journal article
Publication Details: Journal of neurophysiology, Vol.90(6), pp.3750-3763
Publisher: United States
DOI: 10.1152/jn.00500.2003
PMID: 12968011
ISSN: 0022-3077
eISSN: 1522-1598
Grant note: HD-03352 / NICHD NIH HHS DC-00657 / NIDCD NIH HHS DC-04290 / NIDCD NIH HHS DC-00116 / NIDCD NIH HHS
Language: English
Date published: 12/2003
Academic Unit: Neurology; Iowa Neuroscience Institute; Neurosurgery; Otolaryngology
Record Identifier: 9984013114702771

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