Journal article
Functional connectivity: a source of variance in the association between cardiorespiratory fitness and cognition?
Neuropsychologia, Vol.48(5), pp.1394-1406
04/2010
DOI: 10.1016/j.neuropsychologia.2010.01.005
PMCID: PMC3708614
PMID: 20079755
Abstract
Over the next 20 years the number of Americans diagnosed with dementia is expected to more than double (CDC, 2007). It is, therefore, an important public health initiative to understand what factors contribute to the longevity of a healthy mind. Both default mode network (DMN) function and increased aerobic fitness have been associated with better cognitive performance and reduced incidence of Alzheimer's disease among older adults. Here we examine the association between aerobic fitness, functional connectivity in the DMN, and cognitive performance. Results showed significant age-related deficits in functional connectivity in both local and distributed DMN pathways. However, in a group of healthy elderly adults, almost half of the age-related disconnections showed increased functional connectivity as a function of aerobic fitness level. Finally, we examine the hypothesis that functional connectivity in the DMN is one source of variance in the relationship between aerobic fitness and cognition. Results demonstrate instances of both specific and global DMN connectivity mediating the relationship between fitness and cognition. We provide the first evidence for functional connectivity as a source of variance in the association between aerobic fitness and cognition, and discuss results in the context of neurobiological theories of cognitive aging and disease.
Details
- Title: Subtitle
- Functional connectivity: a source of variance in the association between cardiorespiratory fitness and cognition?
- Creators
- Michelle W Voss - Beckman Institute & Department of Psychology, University of Illinois at Urbana-Champaign, 405 N. Mathews Ave, Urbana, IL 61801, USA. mvoss@illinois.eduKirk I EricksonRuchika S PrakashLaura ChaddockEdward MalkowskiHeloisa AlvesJennifer S KimKatherine S MorrisSiobhan M WhiteThomas R WójcickiLiang HuAmanda SzaboEmily KlammEdward McAuleyArthur F Kramer
- Resource Type
- Journal article
- Publication Details
- Neuropsychologia, Vol.48(5), pp.1394-1406
- DOI
- 10.1016/j.neuropsychologia.2010.01.005
- PMID
- 20079755
- PMCID
- PMC3708614
- NLM abbreviation
- Neuropsychologia
- ISSN
- 0028-3932
- eISSN
- 1873-3514
- Publisher
- England
- Grant note
- R37 AG025667 / NIA NIH HHS R01 AG025032 / NIA NIH HHS R01 AG25032 / NIA NIH HHS R37 AG025667-05 / NIA NIH HHS R01 AG025667 / NIA NIH HHS R01 AG25667 / NIA NIH HHS
- Language
- English
- Date published
- 04/2010
- Academic Unit
- Psychological and Brain Sciences; Iowa Neuroscience Institute
- Record Identifier
- 9984002490102771
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