Journal article
Functional evidence for the rapid desensitization of 5-HT3 receptors on vagal afferents mediating the Bezold–Jarisch reflex
Brain research, Vol.873(2), pp.302-305
08/2000
DOI: 10.1016/S0006-8993(00)02526-9
PMID: 10930559
Abstract
The aim of this study was to determine whether 5-hydroxytryptamine (5- HT)3 receptors on cardiopulmonary afferents mediating the Bezold-Jarisch reflex (BJR) desensitize upon repeated exposure to selective agonists. BJR- mediated falls in heart rate, diastolic arterial blood pressure and cardiac output elicited by the 5-HT3-receptor agonists, phenylbiguanide (100 μg/kg, i.v.) or 2-methyl-5-HT (100 μg/kg, i.v.), progressively diminished upon repeated injection in conscious rats. The BJR responses elicited by 5-HT (40 μg/kg, i.v.) were markedly reduced in rats which had received the above injections of phenylbiguanide or 2-methyl-5-HT whereas the BJR responses elicited by L-S-nitrosocysteine (10 μmol/kg, i.v.) were similar before and after the injections of the 5-HT3 receptor agonists. These findings suggest that tachyphylaxis to 5-HT3 receptor agonists may be due to the desensitization of 5-HT3 receptors on cardiopulmonary afferents rather than the impairment of the central or peripheral processing of the BJR. (C) 2000 Elsevier Science B.V.
Details
- Title: Subtitle
- Functional evidence for the rapid desensitization of 5-HT3 receptors on vagal afferents mediating the Bezold–Jarisch reflex
- Creators
- Erin J WhalenAlan Kim JohnsonStephen J Lewis
- Resource Type
- Journal article
- Publication Details
- Brain research, Vol.873(2), pp.302-305
- DOI
- 10.1016/S0006-8993(00)02526-9
- PMID
- 10930559
- ISSN
- 0006-8993
- eISSN
- 1872-6240
- Language
- English
- Date published
- 08/2000
- Academic Unit
- Psychological and Brain Sciences; Neuroscience and Pharmacology; Health and Human Physiology
- Record Identifier
- 9984213269002771
Metrics
15 Record Views