Functional evolution of ADAMTS genes: Evidence from analyses of phylogeny and gene organization

Ainsley C Nicholson; Shehre-Banoo Malik; John M Logsdon; Erwin G Van Meir

doi:10.1186/1471-2148-5-11

Back

Functional evolution of ADAMTS genes: Evidence from analyses of phylogeny and gene organization

Journal article

Open access

Peer reviewed

Functional evolution of ADAMTS genes: Evidence from analyses of phylogeny and gene organization

Ainsley C Nicholson, Shehre-Banoo Malik, John M Logsdon and Erwin G Van Meir

BMC evolutionary biology, Vol.5(1), pp.11-11

02/04/2005

DOI: 10.1186/1471-2148-5-11

PMCID: PMC549037

PMID: 15693998

Files and links (1)

url

https://doi.org/10.1186/1471-2148-5-11View

Published (Version of record) Open Access

Abstract

Background: The ADAMTS (A Disintegrin-like and Metalloprotease with Thrombospondin motifs) proteins are a family of metalloproteases with sequence similarity to the ADAM proteases, that contain the thrombospondin type 1 sequence repeat motifs (TSRs) common to extracellular matrix proteins. ADAMTS proteins have recently gained attention with the discovery of their role in a variety of diseases, including tissue and blood disorders, cancer, osteoarthritis, Alzheimer's and the genetic syndromes Weill-Marchesani syndrome (ADAMTS10), thrombotic thrombocytopenic purpura (ADAMTS13), and Ehlers-Danlos syndrome type VIIC (ADAMTS2) in humans and belted white-spotting mutation in mice (ADAMTS20). Results: Phylogenetic analysis and comparison of the exon/intron organization of vertebrate (Homo, Mus, Fugu), chordate (Ciona) and invertebrate (Drosophila and Caenorhabditis) ADAMTS homologs has elucidated the evolutionary relationships of this important gene family, which comprises 19 members in humans. Conclusions: The evolutionary history of ADAMTS genes in vertebrate genomes has been marked by rampant gene duplication, including a retrotransposition that gave rise to a distinct ADAMTS subfamily (ADAMTS1, -4, -5, -8, -15) that may have distinct aggrecanase and angiogenesis functions. © 2005 Nicholson et al; licensee BioMed Central Ltd.

Details

Title: Subtitle: Functional evolution of ADAMTS genes: Evidence from analyses of phylogeny and gene organization
Creators: Ainsley C Nicholson - Laboratory of Molecular Neuro-Oncology, Neurosurgery Department and Winship Cancer Institute, 1365-C Clifton Road, Room C5078, Emory University, Atlanta GA 30322 USA Roy J. Carver Center for Comparative Genomics, Department of Biological Sciences, 300 Old Biology Building, University of Iowa, Iowa City IA 52242-1324 USA
Shehre-Banoo Malik - Laboratory of Molecular Neuro-Oncology, Neurosurgery Department and Winship Cancer Institute, 1365-C Clifton Road, Room C5078, Emory University, Atlanta GA 30322 USA Roy J. Carver Center for Comparative Genomics, Department of Biological Sciences, 300 Old Biology Building, University of Iowa, Iowa City IA 52242-1324 USA
John M Logsdon - Laboratory of Molecular Neuro-Oncology, Neurosurgery Department and Winship Cancer Institute, 1365-C Clifton Road, Room C5078, Emory University, Atlanta GA 30322 USA Roy J. Carver Center for Comparative Genomics, Department of Biological Sciences, 300 Old Biology Building, University of Iowa, Iowa City IA 52242-1324 USA
Erwin G Van Meir - Laboratory of Molecular Neuro-Oncology, Neurosurgery Department and Winship Cancer Institute, 1365-C Clifton Road, Room C5078, Emory University, Atlanta GA 30322 USA Roy J. Carver Center for Comparative Genomics, Department of Biological Sciences, 300 Old Biology Building, University of Iowa, Iowa City IA 52242-1324 USA
Resource Type: Journal article
Publication Details: BMC evolutionary biology, Vol.5(1), pp.11-11
DOI: 10.1186/1471-2148-5-11
PMID: 15693998
PMCID: PMC549037
NLM abbreviation: BMC Evol Biol
ISSN: 1471-2148
eISSN: 1471-2148
Publisher: BioMed Central
Language: English
Date published: 02/04/2005
Academic Unit: Biology
Record Identifier: 9984217411802771

Metrics

12 Record Views

76 Times Cited - Web of Science