Journal article
Functional imaging in Huntington's disease
Experimental neurology, Vol.216(2), pp.272-277
04/01/2009
DOI: 10.1016/j.expneurol.2008.12.015
PMCID: PMC3810959
PMID: 19171138
Abstract
Huntington's disease (HD) is a genetic brain disease characterized by loss of capacity in movement control, cognition, and emotional regulation over a period of about 30 years. Since it is well established that clinical impairments and brain atrophy can be detected decades prior to receiving a clinical diagnosis, functional neuroimaging efforts have gained momentum in HD research. In most brain disorders, there is accumulating evidence that the clinical manifestations of disease do not simply depend on the extent of tissue loss, but represent a complex balance among neuronal dysfunction, tissue repair, and circuitry reorganization. Based upon this premise, functional neuroimaging modalities may be more sensitive to the earliest changes in HD than are structural imaging approaches. For this review, PET and fMRI studies conducted in HD samples were summarized. Strengths and limitations of the utilization of functional imaging in HD are discussed and recommendations are offered to facilitate future research endeavors.
Details
- Title: Subtitle
- Functional imaging in Huntington's disease
- Creators
- Jane S. Paulsen - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Experimental neurology, Vol.216(2), pp.272-277
- Publisher
- Elsevier Inc
- DOI
- 10.1016/j.expneurol.2008.12.015
- PMID
- 19171138
- PMCID
- PMC3810959
- ISSN
- 0014-4886
- eISSN
- 1090-2430
- Language
- English
- Date published
- 04/01/2009
- Academic Unit
- Psychiatry; Psychological and Brain Sciences
- Record Identifier
- 9984383284702771
Metrics
3 Record Views