Journal article
Functional imaging of the lungs with gas agents
Journal of magnetic resonance imaging, Vol.43(2), pp.295-315
02/2016
DOI: 10.1002/jmri.25002
PMCID: PMC4733870
PMID: 26218920
Abstract
This review focuses on the state-of-the-art of the three major classes of gas contrast agents used in magnetic resonance imaging (MRI)-hyperpolarized (HP) gas, molecular oxygen, and fluorinated gas--and their application to clinical pulmonary research. During the past several years there has been accelerated development of pulmonary MRI. This has been driven in part by concerns regarding ionizing radiation using multidetector computed tomography (CT). However, MRI also offers capabilities for fast multispectral and functional imaging using gas agents that are not technically feasible with CT. Recent improvements in gradient performance and radial acquisition methods using ultrashort echo time (UTE) have contributed to advances in these functional pulmonary MRI techniques. The relative strengths and weaknesses of the main functional imaging methods and gas agents are compared and applications to measures of ventilation, diffusion, and gas exchange are presented. Functional lung MRI methods using these gas agents are improving our understanding of a wide range of chronic lung diseases, including chronic obstructive pulmonary disease, asthma, and cystic fibrosis in both adults and children.
Details
- Title: Subtitle
- Functional imaging of the lungs with gas agents
- Creators
- Stanley J Kruger - Department of Medical Physics, University of Wisconsin, Madison, Wisconsin, USAScott K Nagle - Department of Pediatrics, University of Wisconsin, Madison, Wisconsin, USAMarcus J Couch - Biotechnology Program, Lakehead University, Thunder Bay, Ontario, CanadaYoshiharu Ohno - Department of Radiology, Kobe University Graduate School of Medicine, Kobe, JapanMitchell Albert - Department of Chemistry, Lakehead University, Thunder Bay, Ontario, CanadaSean B Fain - Department of Biomedical Engineering, University of Wisconsin, Madison, Wisconsin, USA
- Resource Type
- Journal article
- Publication Details
- Journal of magnetic resonance imaging, Vol.43(2), pp.295-315
- DOI
- 10.1002/jmri.25002
- PMID
- 26218920
- PMCID
- PMC4733870
- NLM abbreviation
- J Magn Reson Imaging
- ISSN
- 1053-1807
- eISSN
- 1522-2586
- Publisher
- United States
- Grant note
- KL2 TR000428 / NCATS NIH HHS UL1 TR000427 / NCATS NIH HHS U10 HL109168 / NHLBI NIH HHS S10 OD016394 / NIH HHS R01 HL064066 / NHLBI NIH HHS
- Language
- English
- Date published
- 02/2016
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Radiology; Electrical and Computer Engineering; Iowa Neuroscience Institute; Health, Sport, and Human Physiology
- Record Identifier
- 9984051581402771
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