Functional lung imaging using hyperpolarized gas MRI

Sean B. Fain; Frank R. Korosec; James H. Holmes; Rafael O'Halloran; Ronald L. Sorkness; Thomas M. Grist

doi:10.1002/jmri.20876

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Functional lung imaging using hyperpolarized gas MRI

Journal article

Open access

Peer reviewed

Functional lung imaging using hyperpolarized gas MRI

Sean B. Fain, Frank R. Korosec, James H. Holmes, Rafael O'Halloran, Ronald L. Sorkness and Thomas M. Grist

Journal of magnetic resonance imaging, Vol.25(5), pp.910-923

05/2007

DOI: 10.1002/jmri.20876

PMID: 17410561

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Abstract

The noninvasive assessment of lung function using imaging is increasingly of interest for the study of lung diseases, including chronic obstructive pulmonary disease (COPD) and asthma. Hyperpolarized gas MRI (HP MRI) has demonstrated the ability to detect changes in ventilation, perfusion, and lung microstructure that appear to be associated with both normal lung development and disease progression. The physical characteristics of HP gases and their application to MRI are presented with an emphasis on current applications. Clinical investigations using HP MRI to study asthma, COPD, cystic fibrosis, pediatric chronic lung disease, and lung transplant are reviewed. Recent advances in polarization, pulse sequence development for imaging with Xe-129, and prototype low magnetic field systems dedicated to lung imaging are highlighted as areas of future development for this rapidly evolving technology. © 2007 Wiley-Liss, Inc.

contrast agents

fast MRI

functional imaging

hyperpolarized gas

lung disease

pulmonary function

Details

Title: Subtitle: Functional lung imaging using hyperpolarized gas MRI
Creators: Sean B. Fain - University of Wisconsin–Madison
Frank R. Korosec - University of Wisconsin–Madison
James H. Holmes - University of Wisconsin–Madison
Rafael O'Halloran - University of Wisconsin–Madison
Ronald L. Sorkness - University of Wisconsin–Madison
Thomas M. Grist - University of Wisconsin–Madison
Resource Type: Journal article
Publication Details: Journal of magnetic resonance imaging, Vol.25(5), pp.910-923
DOI: 10.1002/jmri.20876
PMID: 17410561
NLM abbreviation: J Magn Reson Imaging
ISSN: 1053-1807
eISSN: 1522-2586
Publisher: Wiley Subscription Services, Inc., A Wiley Company
Number of pages: 14
Language: English
Date published: 05/2007
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Radiology; Electrical and Computer Engineering; Health, Sport, and Human Physiology
Record Identifier: 9984274955602771

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