Functional organization of human auditory cortex: investigation of response latencies through direct recordings

Kirill V Nourski; Mitchell Steinschneider; Bob McMurray; Christopher K Kovach; Hiroyuki Oya; Hiroto Kawasaki; Matthew A Howard III

doi:10.1016/j.neuroimage.2014.07.004

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Functional organization of human auditory cortex: investigation of response latencies through direct recordings

Journal article

Peer reviewed

Functional organization of human auditory cortex: investigation of response latencies through direct recordings

Kirill V Nourski, Mitchell Steinschneider, Bob McMurray, Christopher K Kovach, Hiroyuki Oya, Hiroto Kawasaki and Matthew A Howard III

NeuroImage (Orlando, Fla.), Vol.101, pp.598-609

11/01/2014

DOI: 10.1016/j.neuroimage.2014.07.004

PMCID: PMC4430832

PMID: 25019680

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https://www.ncbi.nlm.nih.gov/pmc/articles/4430832View

Open Access

Abstract

The model for functional organization of human auditory cortex is in part based on findings in non-human primates, where the auditory cortex is hierarchically delineated into core, belt and parabelt fields. This model envisions that core cortex directly projects to belt, but not to parabelt, whereas belt regions are a major source of direct input for auditory parabelt. In humans, the posteromedial portion of Heschl's gyrus (HG) represents core auditory cortex, whereas the anterolateral portion of HG and the posterolateral superior temporal gyrus (PLST) are generally interpreted as belt and parabelt, respectively. In this scheme, response latencies can be hypothesized to progress in serial fashion from posteromedial to anterolateral HG to PLST. We examined this hypothesis by comparing response latencies to multiple stimuli, measured across these regions using simultaneous intracranial recordings in neurosurgical patients. Stimuli were 100 Hz click trains and the speech syllable /da/. Response latencies were determined by examining event-related band power in the high gamma frequency range. The earliest responses in auditory cortex occurred in posteromedial HG. Responses elicited from sites in anterolateral HG were neither earlier in latency from sites on PLST, nor more robust. Anterolateral HG and PLST exhibited some preference for speech syllable stimuli compared to click trains. These findings are not supportive of a strict serial model envisioning principal flow of information along HG to PLST. In contrast, data suggest that a portion of PLST may represent a relatively early stage in the auditory cortical hierarchy.

Humans

Middle Aged

Male

Electrodes, Implanted

Auditory Cortex - physiology

Brain Mapping - methods

Reaction Time - physiology

Auditory Cortex - anatomy & histology

Auditory Perception - physiology

Gamma Rhythm - physiology

Electroencephalography - methods

Speech Perception - physiology

Young Adult

Evoked Potentials, Auditory - physiology

Adult

Female

Details

Title: Subtitle: Functional organization of human auditory cortex: investigation of response latencies through direct recordings
Creators: Kirill V Nourski - Department of Neurosurgery, The University of Iowa, Iowa City, IA, 52242 USA
Mitchell Steinschneider - Department of Neurology, Department of Neuroscience, Albert Einstein College of Medicine, New York, NY 10461, USA
Bob McMurray - Department of Psychology, Department of Communication Sciences and Disorders, Department of Linguistics, The University of Iowa, Iowa City, IA, 52242 USA
Christopher K Kovach - Department of Neurosurgery, The University of Iowa, Iowa City, IA, 52242 USA
Hiroyuki Oya - Department of Neurosurgery, The University of Iowa, Iowa City, IA, 52242 USA
Hiroto Kawasaki - Department of Neurosurgery, The University of Iowa, Iowa City, IA, 52242 USA
Matthew A Howard III - Department of Neurosurgery, The University of Iowa, Iowa City, IA, 52242 USA
Resource Type: Journal article
Publication Details: NeuroImage (Orlando, Fla.), Vol.101, pp.598-609
DOI: 10.1016/j.neuroimage.2014.07.004
PMID: 25019680
PMCID: PMC4430832
NLM abbreviation: Neuroimage
ISSN: 1053-8119
eISSN: 1095-9572
Publisher: United States
Grant note: R01-DC008089 / NIDCD NIH HHS R01-DC00657 / NIDCD NIH HHS R01 DC008089 / NIDCD NIH HHS R01 DC000657 / NIDCD NIH HHS UL1RR024979 / NCRR NIH HHS P50 DC000242 / NIDCD NIH HHS R01-DC04290 / NIDCD NIH HHS R01 DC004290 / NIDCD NIH HHS UL1 RR024979 / NCRR NIH HHS
Language: English
Date published: 11/01/2014
Academic Unit: Neurology; Communication Sciences and Disorders; Linguistics; Psychological and Brain Sciences; Iowa Neuroscience Institute; Neurosurgery; Otolaryngology
Record Identifier: 9984020785202771

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