Functional recovery and histomorphometric assessment following tibial nerve injury in the mouse

Laura T George; Terence M Myckatyn; John N Jensen; Daniel A Hunter; Susan E Mackinnon

doi:10.1055/s-2003-37190

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Functional recovery and histomorphometric assessment following tibial nerve injury in the mouse

Journal article

Peer reviewed

Functional recovery and histomorphometric assessment following tibial nerve injury in the mouse

Laura T George, Terence M Myckatyn, John N Jensen, Daniel A Hunter and Susan E Mackinnon

Journal of reconstructive microsurgery, Vol.19(1), pp.41-47

2003

DOI: 10.1055/s-2003-37190

PMID: 12582966

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Abstract

Longitudinal studies have established that functional recovery following sciatic nerve injury can be evaluated in the mouse. Injury to the tibial nerve offers several advantages to sciatic nerve injury, including improved lower extremity sensation and end-organ reinnervation. Functional recovery following tibial nerve crush injury was studied in 55 C3H mice randomized into five groups harvested for histomorphometric evaluation from either normal nerves or 2, 3, 4, or 6 weeks postoperatively. Walking tracks were obtained preoperatively, and at regular intervals postoperatively, and foot print lengths measured. Significant normalization of print length occurred 14 days postoperatively, and complete recovery was noted 28 days postoperatively. Significant histomorphologic evidence of neuroregeneration was detected between 2 and 4 weeks postoperatively. Injury to the tibial nerve is a viable alternative to the sciatic nerve for studying neural regeneration in mice, and the print length factor can be used to monitor functional recovery in this model.

Neurosurgery

Biological and medical sciences

Cranial nerves. Peripheral nerves. Autonomic nervous system

Injuries of the nervous system and the skull. Diseases due to physical agents

Medical sciences

Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases

Traumas. Diseases due to physical agents

Details

Title: Subtitle: Functional recovery and histomorphometric assessment following tibial nerve injury in the mouse
Creators: Laura T George - Washington University in St. Louis
Terence M Myckatyn - Division of Plastic and Reconstructive Surgery, Washington University School of Medicine, St. Louis, MO, United States
John N Jensen - Division of Plastic and Reconstructive Surgery, Washington University School of Medicine, St. Louis, MO, United States
Daniel A Hunter - Division of Plastic and Reconstructive Surgery, Washington University School of Medicine, St. Louis, MO, United States
Susan E Mackinnon - Division of Plastic and Reconstructive Surgery, Washington University School of Medicine, St. Louis, MO, United States
Resource Type: Journal article
Publication Details: Journal of reconstructive microsurgery, Vol.19(1), pp.41-47
Publisher: Thieme
DOI: 10.1055/s-2003-37190
PMID: 12582966
ISSN: 0743-684X
eISSN: 1098-8947
Number of pages: 7
Language: English
Date published: 2003
Academic Unit: Surgery
Record Identifier: 9984701648102771

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