Journal article
Functional role of AMP-activated protein kinase in the heart during exercise
FEBS letters, Vol.579(10), pp.2045-2050
2005
DOI: 10.1016/j.febslet.2005.02.052
PMID: 15811316
Abstract
AMP-activated protein kinase (AMPK) plays a critical role in maintaining energy homeostasis and cardiac function during ischemia in the heart. However, the functional role of AMPK in the heart during exercise is unknown. We examined whether acute exercise increases AMPK activity in mouse hearts and determined the significance of these increases by studying transgenic (TG) mice expressing a cardiac-specific dominant-negative (inactivating) AMPKα2 subunit. Exercise increased cardiac AMPKα2 activity in the wild type mice but not in TG. We found that inactivation of AMPK did not result in abnormal ATP and glycogen consumption during exercise, cardiac function assessed by heart rhythm telemetry and stress echocardiography, or in maximal exercise capacity.
Details
- Title: Subtitle
- Functional role of AMP-activated protein kinase in the heart during exercise
- Creators
- Nicolas Musi - Research Division, Joslin Diabetes Center, One Joslin Place, Boston, MA 02215, USAMichael F Hirshman - Research Division, Joslin Diabetes Center, One Joslin Place, Boston, MA 02215, USAMichael Arad - Department of Genetics, Division of Cardiovascular Medicine, Brigham and Women’s Hospital, Boston, MA, USAYanqiu Xing - Department of NMR Laboratory, Division of Cardiovascular Medicine, Brigham and Women’s Hospital, Boston, MA, USANobuharu Fujii - Research Division, Joslin Diabetes Center, One Joslin Place, Boston, MA 02215, USAJason Pomerleau - Research Division, Joslin Diabetes Center, One Joslin Place, Boston, MA 02215, USAFerhaan Ahmad - Department of Genetics, Division of Cardiovascular Medicine, Brigham and Women’s Hospital, Boston, MA, USACharles I Berul - Department of Cardiology, Children’s Hospital, Harvard Medical School, Boston, MA, USAJon G Seidman - Department of Genetics, Division of Cardiovascular Medicine, Brigham and Women’s Hospital, Boston, MA, USARong Tian - Department of NMR Laboratory, Division of Cardiovascular Medicine, Brigham and Women’s Hospital, Boston, MA, USALaurie J Goodyear - Research Division, Joslin Diabetes Center, One Joslin Place, Boston, MA 02215, USA
- Resource Type
- Journal article
- Publication Details
- FEBS letters, Vol.579(10), pp.2045-2050
- DOI
- 10.1016/j.febslet.2005.02.052
- PMID
- 15811316
- NLM abbreviation
- FEBS Lett
- ISSN
- 0014-5793
- eISSN
- 1873-3468
- Publisher
- Elsevier B.V
- Language
- English
- Date published
- 2005
- Academic Unit
- Radiology; Molecular Physiology and Biophysics; Cardiovascular Medicine; Fraternal Order of Eagles Diabetes Research Center; Internal Medicine
- Record Identifier
- 9984025596602771
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