Journal article
Functional significance of coronary collateral vessels in patients with coronary artery disease
The American heart journal, Vol.104(2), pp.221-225
08/1982
DOI: 10.1016/0002-8703(82)90196-X
PMID: 7102505
Abstract
Regional myocardial perfusion was measured in 12 normal subjects and in 34 patients with coronary artery disease (CAD) at rest and during infusion of isoproterenol. Increments in regional flows normalized for change in heart rate-systolic product were 91 ± 28% (S.D.) in normals, 71 ± 44% in normal regions in diseased hearts, 58 ± 33% in regions supplied by 50% to 70% stenosed arteries, 35 ± 32% in regions supplied by arteries stenosed by more than 70%, and 16 ± 27% in regions supplied by collateral vessels only. In 3 of 14 regions perfused entirely via collateral pathways, regional perfusion decreased with isoproterenol. Therefore the extent to which coronary flow reserve estimated with isoproterenol was compromised varied directly with the severity of anatomic coronary artery lesions and, in some regions entirely perfused by collateral vessels, an increase in heart rate-systolic pressure product was accompanied by a decrease in perfusion below resting levels. It is concluded that collateral vessels effectively maintain flow rates at normal levels at rest but tent to be inefficient at delivering blood when myocardial oxygen demand is increased.
Details
- Title: Subtitle
- Functional significance of coronary collateral vessels in patients with coronary artery disease
- Creators
- Lawrence D Horwitz - Audie L. Murphy Veterans Administration Hospital San Antonio, Texas USABertron M Groves - Audie L. Murphy Veterans Administration Hospital San Antonio, Texas USARichard A Walsh - Audie L. Murphy Veterans Administration Hospital San Antonio, Texas USASherman M Sorensen - Audie L. Murphy Veterans Administration Hospital San Antonio, Texas USATerry W Latson - Audie L. Murphy Veterans Administration Hospital San Antonio, Texas USA
- Resource Type
- Journal article
- Publication Details
- The American heart journal, Vol.104(2), pp.221-225
- Publisher
- Mosby, Inc
- DOI
- 10.1016/0002-8703(82)90196-X
- PMID
- 7102505
- ISSN
- 0002-8703
- eISSN
- 1097-6744
- Language
- English
- Date published
- 08/1982
- Academic Unit
- Cardiovascular Medicine; Internal Medicine
- Record Identifier
- 9984656540202771
Metrics
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