Journal article
Functionally distinct subsets of human γ/δ T cells
European journal of immunology, Vol.21(12), pp.2999-3007
12/1991
DOI: 10.1002/eji.1830211215
PMID: 1684157
Abstract
To determine if effector subsets exist among human γ/δ T cells, we examined the cytokine production and cytotoxic activity of γ/δ T cell clones with different accessory molecule phenotypes, Vδ and Vγ gene expression, and Jγ rearrangements. T cell clones bearing γ/δ T cell receptor produce an array of cytokines like α/β T cell clones. Individual γ/δ T cell clones produced a characteristic array of cytokines without correlation with Vδ or Vγ gene expression. However, when phenotypic subsets were considered, CD4+ γ/δ clones produced significantly higher levels of interleukin 2 and granulocyte‐monocyte colony‐stimulating factor compared with CD4−CD8− and CD8+ γ/δ clones. Similarly, when cytotoxic potential was assessed, CD4+ γ/δ clones exhibited minimal activity when compared with CD4−CD8− and CD8+ adult peripheral blood γ/δ clones. We conclude that functionally distinct γ/δ T cell subsets exist and suggest that these subsets may correlate with expression of the CD4 accessory molecule.
Details
- Title: Subtitle
- Functionally distinct subsets of human γ/δ T cells
- Creators
- Craig T MoritaSunita VermaPedro AparicioCarlos Martinez‐AHergen SpitsMichael B Brenner
- Resource Type
- Journal article
- Publication Details
- European journal of immunology, Vol.21(12), pp.2999-3007
- Publisher
- WILEY‐VCH Verlag GmbH
- DOI
- 10.1002/eji.1830211215
- PMID
- 1684157
- ISSN
- 0014-2980
- eISSN
- 1521-4141
- Number of pages
- 9
- Grant note
- NIH M.E.C.
- Language
- English
- Date published
- 12/1991
- Academic Unit
- Immunology; Internal Medicine
- Record Identifier
- 9984094624402771
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