Functions of the FAK family kinases in T cells: beyond actin cytoskeletal rearrangement

Nicole Chapman; Jon Houtman

doi:10.1007/s12026-014-8527-y

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Functions of the FAK family kinases in T cells: beyond actin cytoskeletal rearrangement

Journal article

Peer reviewed

Functions of the FAK family kinases in T cells: beyond actin cytoskeletal rearrangement

Nicole Chapman and Jon Houtman

Immunologic research, Vol.59(1), pp.23-34

08/2014

DOI: 10.1007/s12026-014-8527-y

PMCID: PMC4125427

PMID: 24816556

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http://doi.org/10.1007/s12026-014-8527-yView

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Abstract

T cells control the focus and extent of adaptive immunity in infectious and pathological diseases. The activation of T cells occurs when the T cell antigen receptor (TCR) and costimulatory and/or adhesion receptors are engaged by their ligands. This process drives signaling that promotes cytoskeletal rearrangement and transcription factor activation, both of which regulate the quality and magnitude of the T cell response. However, it is not fully understood how different receptor-induced signals combine to alter T cell activation. The related non-receptor tyrosine kinases focal adhesion kinase (FAK) and proline-rich tyrosine kinase 2 (Pyk2) are phosphorylated downstream of the TCR and several costimulatory and adhesion receptors. FAK family proteins integrate receptor-mediated signals that influence actin cytoskeletal rearrangement and effector T cell responses. In this review, we summarize the receptor-specific roles that FAK and Pyk2 control to influence T cell development and activation.

Allergology

FAK

Signal transduction

Immunology

Medicine & Public Health

Pyk2

Cytoskeletal rearrangement

Internal Medicine

Csk

T cells

Medicine/Public Health, general

Details

Title: Subtitle: Functions of the FAK family kinases in T cells: beyond actin cytoskeletal rearrangement
Creators: Nicole Chapman - Department of Immunology, MS 351 St. Jude Children’s Research Hospital 262 Danny Thomas Place Memphis TN 38105 USA
Jon Houtman - Department of Microbiology University of Iowa 2220 MERF Iowa City IA 52242 USA
Contributors: Gail A Bishop (Editor)
Resource Type: Journal article
Publication Details: Immunologic research, Vol.59(1), pp.23-34
DOI: 10.1007/s12026-014-8527-y
PMID: 24816556
PMCID: PMC4125427
NLM abbreviation: Immunol Res
ISSN: 0257-277X
eISSN: 1559-0755
Publisher: Springer US
Language: English
Date published: 08/2014
Academic Unit: Microbiology and Immunology; President; Fraternal Order of Eagles Diabetes Research Center; Internal Medicine
Record Identifier: 9984094516502771

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