Fundus changes in central retinal vein occlusion

Sohan Singh Hayreh; M Bridget Zimmerman

doi:10.1097/iae.0000000000000256

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Fundus changes in central retinal vein occlusion

Journal article

Open access

Peer reviewed

Fundus changes in central retinal vein occlusion

Sohan Singh Hayreh and M Bridget Zimmerman

Retina (Philadelphia, Pa.), Vol.35(1), pp.29-42

01/2015

DOI: 10.1097/iae.0000000000000256

PMCID: PMC4276535

PMID: 25084156

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http://doi.org/10.1097/IAE.0000000000000256View

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Abstract

To investigate systematically the retinal and optic disk changes in central retinal vein occlusion (CRVO) and their natural history. This study comprised 562 consecutive patients with CRVO (492 nonischemic [NI-CRVO] and 89 ischemic CRVO [I-CRVO] eyes) seen within 3 months of onset. Ophthalmic evaluation at initial and follow-up visits included recording visual acuity, visual fields, and detailed anterior segment and fundus examinations and fluorescein fundus angiography. Retinal and subinternal limiting membrane hemorrhages and optic disk edema in I-CRVO were initially more marked (P < 0.0001) and took longer to resolve (P < 0.015) than that in NI-CRVO. Initially, macular edema was more marked in I-CRVO than that in NI-CRVO (P < 0.0001) but did not significantly differ in resolution time (P = 0.238). Macular retinal epithelial pigment degeneration, serous macular detachment, and retinal perivenous sheathing developed at a higher rate in I-CRVO than that in NI-CRVO (P < 0.0001). Ischemic CRVO had more retinal venous engorgement than NI-CRVO (P = 0.003). Fluorescein fundus angiography showed significantly more fluorescein leakage, retinal capillary dilatation, capillary obliteration, and broken capillary foveal arcade (P < 0.0001) in I-CRVO than NI-CRVO. Resolution time of CRVO was longer for I-CRVO than NI-CRVO (P < 0.0001). Characteristics and natural history of fundus findings in the two types of CRVO are different.

Visual Fields - physiology

Humans

Middle Aged

Male

Retinal Vein Occlusion - complications

Papilledema - physiopathology

Retinal Hemorrhage - diagnosis

Aged, 80 and over

Adult

Female

Visual Acuity - physiology

Fluorescein Angiography

Retinal Hemorrhage - physiopathology

Retinal Vein Occlusion - physiopathology

Retinal Vein Occlusion - diagnosis

Epiretinal Membrane - diagnosis

Retinal Hemorrhage - complications

Macular Edema - physiopathology

Adolescent

Macular Edema - diagnosis

Papilledema - complications

Papilledema - diagnosis

Aged

Epiretinal Membrane - complications

Epiretinal Membrane - physiopathology

Macular Edema - complications

Fundus Oculi

Optic Disk - pathology

Details

Title: Subtitle: Fundus changes in central retinal vein occlusion
Creators: Sohan Singh Hayreh - Department of Ophthalmology and Visual Sciences, College of Medicine, University of Iowa, Iowa City, Iowa; and †Department of Biostatistics, College of Public Health, University of Iowa, Iowa City, Iowa
M Bridget Zimmerman
Resource Type: Journal article
Publication Details: Retina (Philadelphia, Pa.), Vol.35(1), pp.29-42
DOI: 10.1097/iae.0000000000000256
PMID: 25084156
PMCID: PMC4276535
NLM abbreviation: Retina
ISSN: 0275-004X
eISSN: 1539-2864
Publisher: United States
Grant note: R01 EY001151 / NEI NIH HHS R01 EY001151-05 / NEI NIH HHS
Language: English
Date published: 01/2015
Academic Unit: Biostatistics; Ophthalmology and Visual Sciences
Record Identifier: 9983997303802771

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