Fundus lesions in malignant hypertension. IV. Focal intraretinal periarteriolar transudates

S S Hayreh; G E Servais; P S Virdi

doi:10.1016/S0161-6420(86)33774-6

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Fundus lesions in malignant hypertension. IV. Focal intraretinal periarteriolar transudates

Journal article

Peer reviewed

Fundus lesions in malignant hypertension. IV. Focal intraretinal periarteriolar transudates

S S Hayreh, G E Servais and P S Virdi

Ophthalmology (Rochester, Minn.), Vol.93(1), pp.60-73

01/1986

DOI: 10.1016/S0161-6420(86)33774-6

PMID: 3951817

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Abstract

Experimental renovascular malignant arterial hypertension was produced in 57 rhesus monkeys by a modified Goldblatt's procedure and their eyes were studied by serial ophthalmoscopy, by stereoscopic color fundus photography, and by fluorescein fundus angiography over a period of months or years. A very common, and one of the earliest, lesions in hypertensive retinopathy was focal intraretinal periarteriolar transudates (FIPTs). In the past, FIPTs have been described erroneously as "cotton-wool spots." The two types of lesions differ very much in shape, size, color, location, fluorescein fundus angiographic pattern, resolution pattern, life cycle, and pathogenesis. FIPTs, on ophthalmoscopy, usually are pinpoint to pinhead size, round or oval, dull white in color, and situated in deeper layers of the retina and beside the major retinal arteries and their main branches. On fluorescein angiography, FIPTs show multiple punctate foci of fluorescein leakage from dilated precapillary retinal arterioles, and there is no focal retinal capillary obliteration. They usually last for two to three weeks, and on resolution leave no ophthalmoscopic, angiographic, or microvascular abnormality. Cotton-wool spots are seen in a variety of retinopathies; FIPTs, however, are a specific retinal lesion of malignant arterial hypertension only. They develop due to breakdown of blood-retinal barrier in pre-capillary retinal arterioles, due to dilatation of the arterioles from failure of autoregulation (caused by severe rise of blood pressure).

Animals

Arterioles

Blood Pressure

Exudates and Transudates - metabolism

Fluorescein Angiography

Fundus Oculi

Hypertension, Malignant - complications

Hypertension, Malignant - metabolism

Hypertension, Malignant - pathology

Hypertension, Malignant - physiopathology

Hypertension, Renovascular - complications

Hypertension, Renovascular - metabolism

Hypertension, Renovascular - pathology

Hypertension, Renovascular - physiopathology

Macaca mulatta

Ophthalmoscopy

Retina - metabolism

Retinal Diseases - etiology

Retinal Vessels - metabolism

Details

Title: Subtitle: Fundus lesions in malignant hypertension. IV. Focal intraretinal periarteriolar transudates
Creators: S S Hayreh - University of Iowa
G E Servais - University of Iowa
P S Virdi - University of Iowa
Resource Type: Journal article
Publication Details: Ophthalmology (Rochester, Minn.), Vol.93(1), pp.60-73
DOI: 10.1016/S0161-6420(86)33774-6
PMID: 3951817
ISSN: 0161-6420
eISSN: 1549-4713
Grant note: EY 1576 / NEI NIH HHS
Language: English
Date published: 01/1986
Academic Unit: Ophthalmology and Visual Sciences
Record Identifier: 9984182761502771

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