Fundus lesions in malignant hypertension. VI. Hypertensive choroidopathy

S S Hayreh; G E Servais; P S Virdi

doi:10.1016/S0161-6420(86)33554-1

Back

Fundus lesions in malignant hypertension. VI. Hypertensive choroidopathy

Journal article

Peer reviewed

Fundus lesions in malignant hypertension. VI. Hypertensive choroidopathy

S S Hayreh, G E Servais and P S Virdi

Ophthalmology (Rochester, Minn.), Vol.93(11), pp.1383-1400

11/1986

DOI: 10.1016/S0161-6420(86)33554-1

PMID: 3808599

View Online

Abstract

Experimental renovascular malignant arterial hypertension was produced, by modified Goldblatt's procedures, in 60 rhesus monkeys, and hypertensive fundus changes were studied in detail (by serial ophthalmoscopy and fluorescein fundus angiography in all monkeys on a long-term follow-up, and pathologically in 29 eyes). In hypertensive choroidopathy, retinal pigment epithelial (RPE) lesions and serous retinal detachment (RD) were the classic ophthalmoscopic lesions, whereas fluorescein fundus angiography and histopathologic studies revealed marked abnormalities in the choroidal vascular bed, in addition to the changes in the RPE. The RPE lesions could be subdivided into initial acute focal lesions (due to focal RPE infarction), and degenerative lesions, which developed later and were progressive in nature, maximally involving the macular and peripheral regions of the fundus. The RD developed most commonly in the posterior pole and infrequently involved the peripheral retina. The choroidal vascular bed showed impaired circulation and extensive occlusive and ischemic changes. These studies revealed that hypertensive choroidopathy is as important a fundus change as hypertensive retinopathy. The pathogenesis of hypertensive choroidopathy is discussed in detail; the evidence indicates that it is due to choroidal ischemia, and that hypertensive choroidopathy and retinopathy are two independent and unrelated manifestations of renovascular malignant hypertension.

Animals

Blood Pressure

Choroid - blood supply

Fluorescein Angiography

Fundus Oculi

Hypertension, Malignant - complications

Hypertension, Malignant - pathology

Hypertension, Renovascular - physiopathology

Macaca mulatta

Ophthalmoscopy

Pigment Epithelium of Eye - pathology

Retinal Detachment - etiology

Uveal Diseases - etiology

Uveal Diseases - pathology

Vascular Diseases - etiology

Details

Title: Subtitle: Fundus lesions in malignant hypertension. VI. Hypertensive choroidopathy
Creators: S S Hayreh - University of Iowa
G E Servais - University of Iowa
P S Virdi - University of Iowa
Resource Type: Journal article
Publication Details: Ophthalmology (Rochester, Minn.), Vol.93(11), pp.1383-1400
DOI: 10.1016/S0161-6420(86)33554-1
PMID: 3808599
ISSN: 0161-6420
eISSN: 1549-4713
Grant note: EY-1576 / NEI NIH HHS
Language: English
Date published: 11/1986
Academic Unit: Ophthalmology and Visual Sciences
Record Identifier: 9984182761602771

Metrics

8 Record Views

112 Times Cited - Web of Science