Fungal Skn7 stress responses and their relationship to virulence

Jan S Fassler; Ann H West

doi:10.1128/EC.00245-10

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Fungal Skn7 stress responses and their relationship to virulence

Journal article

Open access

Peer reviewed

Fungal Skn7 stress responses and their relationship to virulence

Jan S Fassler and Ann H West

Eukaryotic cell, Vol.10(2), pp.156-167

02/2011

DOI: 10.1128/EC.00245-10

PMCID: PMC3067409

PMID: 21131436

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Abstract

The histidine kinase-based phosphorelay has emerged as a common strategy among bacteria, fungi, protozoa, and plants for triggering important stress responses and interpreting developmental cues in response to environmental as well as chemical, nutritional, and hormone signals. The absence of this type of signaling mechanism in animals makes the so-called "two-component" pathway an attractive target for development of antimicrobial agents. The best-studied eukaryotic example of a two-component pathway is the SLN1 pathway in Saccharomyces cerevisiae, which responds to turgor and other physical properties associated with the fungal cell wall. One of the two phosphoreceiver proteins known as response regulators in this pathway is Skn7, a highly conserved stress-responsive transcription factor with a subset of activities that are dependent on SLN1 pathway phosphorylation and another subset that are independent. Interest in Skn7as a determinant in fungal virulence stems primarily from its well-established role in the oxidative stress response; however, the involvement of Skn7 in maintenance of cell wall integrity may also be relevant. Since the cell wall is crucial for fungal survival, structural and biosynthetic proteins affecting wall composition and signaling pathways that respond to wall stress are likely to play key roles in virulence. Here we review the molecular and phenotypic characteristics of different fungal Skn7 proteins and consider how each of these properties may contribute to fungal virulence.

Gene Expression Regulation, Fungal

Amino Acid Sequence

Saccharomyces cerevisiae - physiology

Virulence

Stress, Physiological

Molecular Sequence Data

Saccharomyces cerevisiae - pathogenicity

Intracellular Signaling Peptides and Proteins - metabolism

Phylogeny

DNA-Binding Proteins - metabolism

Transcription Factors - metabolism

Phenotype

Sequence Alignment

Fungi - physiology

Saccharomyces cerevisiae Proteins - metabolism

Fungi - pathogenicity

Drug Resistance, Fungal

Fungal Proteins - metabolism

Details

Title: Subtitle: Fungal Skn7 stress responses and their relationship to virulence
Creators: Jan S Fassler - Department of Biology, University of Iowa, Iowa City, IA 52242, USA. jan-fassler@uiowa.edu
Ann H West
Resource Type: Journal article
Publication Details: Eukaryotic cell, Vol.10(2), pp.156-167
DOI: 10.1128/EC.00245-10
PMID: 21131436
PMCID: PMC3067409
NLM abbreviation: Eukaryot Cell
ISSN: 1535-9778
eISSN: 1535-9786
Publisher: American Society for Microbiology; United States
Grant note: GM59311 / NIGMS NIH HHS R01 GM068746 / NIGMS NIH HHS R01 GM059311 / NIGMS NIH HHS GM68746 / NIGMS NIH HHS R01 GM056719 / NIGMS NIH HHS GM56719 / NIGMS NIH HHS
Language: English
Date published: 02/2011
Academic Unit: Biology
Record Identifier: 9983992093702771

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