Journal article
Fungal Translocation Is Associated with Immune Activation and Systemic Inflammation in Treated HIV
AIDS research and human retroviruses, Vol.35(5), pp.461-472
05/2019
DOI: 10.1089/AID.2018.0252
PMCID: PMC6516070
PMID: 30784316
Abstract
The mechanisms causing HIV-associated immune activation remain incompletely understood. Alteration of intestinal integrity with subsequent translocation of bacterial products appears to play an important role; however, little is known about the impact of fungal translocation. We assessed the effect of fungal translocation and its association with immune activation in people living with HIV (PLWH) compared with uninfected controls. We measured serum levels of β-D-glucan (BDG) and anti-
antibodies (ASCA) immunoglobulin G (IgG) and immunoglobulin A (IgA) and markers of systemic inflammation and immune activation in virally suppressed PLWH on antiretroviral therapy (ART) and uninfected controls. T-test and Mann-Whitney tests were used to compare markers by HIV status and correlation and regression analyses were used to assess associations of fungal translocation markers with markers of inflammation. One hundred seventy-six participants were included (128 HIV+ and 48 HIV-); 72% male, 65% African American, median age was 50 years, and CD4 was 710 cells/cm
. Levels of BDG tended to be lower in HIV+ when compared with controls (
= .05). No significant difference in levels of ASCA IgG and IgA was seen between groups (
> .75). There was a significant correlation between BDG and several markers of inflammation and immune activation in PLWH, not seen in uninfected controls. In contrast, no correlations were seen between levels of ASCA IgG and IgA with inflammatory markers. PLWH on ART do not have higher levels of BDG or ASCA when compared with uninfected controls, however, the association found between BDG and several inflammation markers suggests a potential role of fungal translocation in the heightened immune activation seen in treated HIV.
Details
- Title: Subtitle
- Fungal Translocation Is Associated with Immune Activation and Systemic Inflammation in Treated HIV
- Creators
- Lukasz D Weiner - 2 Rainbow Babies and Children's Hospital, Cleveland, OhioMauricio Retuerto - 4 Center for Medical Mycology, Case Western Reserve University and University Hospitals Cleveland Medical Center, Cleveland, OhioChristopher L Hager - 4 Center for Medical Mycology, Case Western Reserve University and University Hospitals Cleveland Medical Center, Cleveland, OhioVanessa El Kamari - 3 Case Western Reserve University, Cleveland, OhioLingpeng Shan - 3 Case Western Reserve University, Cleveland, OhioAbdus Sattar - 3 Case Western Reserve University, Cleveland, OhioManjusha Kulkarni - 5 Ohio State University School of Health and Rehabilitation Sciences, Columbus, OhioNicholas Funderburg - 5 Ohio State University School of Health and Rehabilitation Sciences, Columbus, OhioMahmoud A Ghannoum - 4 Center for Medical Mycology, Case Western Reserve University and University Hospitals Cleveland Medical Center, Cleveland, OhioSahera Dirajlal-Fargo - 3 Case Western Reserve University, Cleveland, OhioGrace A McComsey - 3 Case Western Reserve University, Cleveland, Ohio
- Resource Type
- Journal article
- Publication Details
- AIDS research and human retroviruses, Vol.35(5), pp.461-472
- DOI
- 10.1089/AID.2018.0252
- PMID
- 30784316
- PMCID
- PMC6516070
- NLM abbreviation
- AIDS Res Hum Retroviruses
- ISSN
- 0889-2229
- eISSN
- 1931-8405
- Grant note
- R00 HL108743 / NHLBI NIH HHS R21 DK118757 / NIDDK NIH HHS K23 HD088295 / NICHD NIH HHS R56 HL126526 / NHLBI NIH HHS R56 HL126539 / NHLBI NIH HHS
- Language
- English
- Date published
- 05/2019
- Academic Unit
- Stead Family Department of Pediatrics; Infectious Disease (Pediatrics)
- Record Identifier
- 9984093220102771
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