Journal article
Further development of YBOCS dimensions in the OCD Collaborative Genetics Study: Symptoms vs Categories
Psychiatry research, Vol.160(1), pp.83-93
07/15/2008
DOI: 10.1016/j.psychres.2007.07.010
PMCID: PMC2819420
PMID: 18514325
Abstract
Despite progress in identifying homogeneous subphenotypes of obsessive compulsive disorder (OCD) through factor analysis of the Yale-Brown Obsessive Compulsive Scale Symptom Checklist (YBOCS-SC), prior solutions have been limited by a reliance on presupposed symptom categories rather than discrete symptoms. Furthermore, there have been only limited attempts to evaluate the familiality of OCD symptom dimensions. The purpose of this study was to extend prior work by this collaborative group in category-based dimensions by conducting the first-ever exploratory dichotomous factor analysis using individual OCD symptoms, comparing these results to a refined category-level solution, and testing the familiality of derived factors. Participants were 485 adults in the six-site OCD Collaborative Genetics Study, diagnosed with lifetime OCD using semi-structured interviews. YBOCS-SC data were factor analyzed at both the individual item and symptom category levels. Factor score intraclass correlations were calculated using a subsample of 145 independent affected sib pairs. The item- and category-level factor analyses yielded nearly identical 5-factor solutions. While significant sib-sib associations were found for 4 of the 5 factors, Hoarding and Taboo Thoughts were the most robustly familial (r
ICC
≥ 0.2). This report presents considerable converging evidence for a 5-factor structural model of OCD symptoms, including separate factor analyses employing individual symptoms and symptom categories, as well as sibling concordance. The results support investigation of this multidimensional model in OCD genetic linkage studies.
Details
- Title: Subtitle
- Further development of YBOCS dimensions in the OCD Collaborative Genetics Study: Symptoms vs Categories
- Creators
- Anthony Pinto - Butler HospitalBenjamin D Greenberg - Butler HospitalMarco A Grados - Johns Hopkins UniversityO. Joseph Bienvenu - Johns Hopkins UniversityJack F Samuels - Johns Hopkins UniversityDennis L Murphy - National Institutes of HealthGregor Hasler - National Institutes of HealthRobert L StoutScott L Rauch - Massachusetts General HospitalYin Y Shugart - Johns Hopkins UniversityDavid L Pauls - Massachusetts General HospitalJames A Knowles - Division of Child and Adolescent Psychiatry, University of California-Los Angeles, School of Medicine, Los Angeles, CA USAAbby J Fyer - Columbia UniversityJames T McCracken - Division of Child and Adolescent Psychiatry, University of California-Los Angeles, School of Medicine, Los Angeles, CA USAJohn Piacentini - Division of Child and Adolescent Psychiatry, University of California-Los Angeles, School of Medicine, Los Angeles, CA USAYing Wang - Johns Hopkins UniversityVirginia L Willour - Johns Hopkins UniversityBernadette Cullen - Johns Hopkins UniversityKung-Yee Liang - Johns Hopkins UniversityRudolf Hoehn-Saric - Johns Hopkins UniversityMark A Riddle - Division of Child and Adolescent Psychiatry, University of California-Los Angeles, School of Medicine, Los Angeles, CA USASteven A Rasmussen - Division of Child and Adolescent Psychiatry, University of California-Los Angeles, School of Medicine, Los Angeles, CA USAGerald Nestadt - Division of Child and Adolescent Psychiatry, University of California-Los Angeles, School of Medicine, Los Angeles, CA USA
- Resource Type
- Journal article
- Publication Details
- Psychiatry research, Vol.160(1), pp.83-93
- DOI
- 10.1016/j.psychres.2007.07.010
- PMID
- 18514325
- PMCID
- PMC2819420
- NLM abbreviation
- Psychiatry Res
- ISSN
- 0165-1781
- eISSN
- 1872-7123
- Language
- English
- Date published
- 07/15/2008
- Academic Unit
- Psychiatry; Iowa Neuroscience Institute
- Record Identifier
- 9984003930902771
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