Journal article
Further lesion evidence for the neural basis of conceptual knowledge for persons and other concrete entities
Journal of neuropsychology, Vol.2(1), pp.301-320
03/2008
DOI: 10.1348/174866407X227033
PMID: 19334316
Abstract
The neural underpinnings of conceptual knowledge have been studied intensively, but many unanswered questions remain. In a previous study examining recognition of persons, animals, and tools in 116 participants with unilateral brain lesions, we found no instance of a patient who manifested defective recognition in all three categories. We reasoned that the spatial distribution of the lesion loci critical for the appearance of recognition defects for these different categories explained why this 'three-way' defect could not be found in patients with unilateral lesions, and we proposed that only a suitable bilateral lesion would be likely to produce such a combined defect. In the study reported here, we tested this hypothesis by investigating recognition performances in 55 participants with bilateral cortical lesions. In support of the hypothesis, nine patients, all of whose lesions included bilateral occipitotemporal and/or temporal cortices, had a three-way recognition impairment (persons, M = 18.3%; animals, M = 35.7%; tools, M = 71.3%; all scores >2 SDs below normal). As expected, bilateral lesions to other neural sectors, for example prefrontal cortices, did not lead to recognition impairments. These findings provide further support for the notion that retrieval of knowledge for concrete entities from different conceptual categories depends on partially segregated neural systems, located in different sectors of occipitotemporal and temporal regions in right and left hemisphere.
Details
- Title: Subtitle
- Further lesion evidence for the neural basis of conceptual knowledge for persons and other concrete entities
- Creators
- Daniel Tranel - Department of Neurology, University of Iowa Hospitals and Clinics, 200 Hawkins Drive, Iowa City, Iowa 52242, USA. daniel-tranel@uiowa.eduJustin FeinsteinKenneth Manzel
- Resource Type
- Journal article
- Publication Details
- Journal of neuropsychology, Vol.2(1), pp.301-320
- DOI
- 10.1348/174866407X227033
- PMID
- 19334316
- NLM abbreviation
- J Neuropsychol
- ISSN
- 1748-6645
- eISSN
- 1748-6653
- Publisher
- England
- Grant note
- R01 DA022549 / NIDA NIH HHS P01 NS19632 / NINDS NIH HHS
- Language
- English
- Date published
- 03/2008
- Academic Unit
- Neurology; Psychological and Brain Sciences; Iowa Neuroscience Institute
- Record Identifier
- 9984002430202771
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