Journal article
G72 influences longitudinal change in frontal lobe volume in schizophrenia
American journal of medical genetics. Part B, Neuropsychiatric genetics, Vol.153B(2), pp.640-647
03/05/2010
DOI: 10.1002/ajmg.b.31033
PMCID: PMC2908546
PMID: 19760675
Abstract
Schizophrenia is a neurodevelopmental psychiatric disorder characterized by a variety of structural brain abnormalities that appear to progress across the course of illness. Schizophrenia also is highly heritable, and one gene that has emerged as a possible susceptibility factor is G72. G72 influences brain development and activity by an as-yet unclear mechanism, and multiple studies have reported associations between G72 and schizophrenia. We were interested in linking these domains of investigation by determining whether G72 also influences the rate of longitudinal structural brain changes in individuals with schizophrenia. As part of the Iowa Longitudinal Study of Recent Onset Psychoses, we genotyped four G72 polymorphisms previously associated with schizophrenia in 110 subjects with schizophrenia or schizoaffective disorder from whom we had obtained two brain MRI scans an average of 3 years apart. The four polymorphisms captured three haplotypes, one of which was strongly associated with an increased rate of frontal lobe volume decrement. This same haplotype was also associated with more severe psychotic symptoms at the time of the second scan. These data thus suggest that variation in G72 modulates the progressive brain changes that characterize schizophrenia.
Details
- Title: Subtitle
- G72 influences longitudinal change in frontal lobe volume in schizophrenia
- Creators
- Sarah M Hartz - Department of Psychiatry, University of Iowa Carver College of Medicine, Iowa City, IowaBeng-Choon Ho - Department of Psychiatry, University of Iowa Carver College of Medicine, Iowa City, IowaNancy C Andreasen - Department of Psychiatry, University of Iowa Carver College of Medicine, Iowa City, IowaAmy Librant - Department of Psychiatry, University of Iowa Carver College of Medicine, Iowa City, IowaDanielle Rudd - Department of Psychiatry, University of Iowa Carver College of Medicine, Iowa City, IowaEric A Epping - Department of Psychiatry, University of Iowa Carver College of Medicine, Iowa City, IowaThomas H Wassink - Department of Psychiatry, University of Iowa Carver College of Medicine, Iowa City, Iowa
- Resource Type
- Journal article
- Publication Details
- American journal of medical genetics. Part B, Neuropsychiatric genetics, Vol.153B(2), pp.640-647
- DOI
- 10.1002/ajmg.b.31033
- PMID
- 19760675
- PMCID
- PMC2908546
- NLM abbreviation
- Am J Med Genet B Neuropsychiatr Genet
- ISSN
- 1552-4841
- eISSN
- 1552-485X
- Publisher
- United States
- Grant note
- MH68380 / NIMH NIH HHS R01 MH080128 / NIMH NIH HHS MH31593 / NIMH NIH HHS MH40856 / NIMH NIH HHS R01 MH031593 / NIMH NIH HHS R01 MH040856 / NIMH NIH HHS UL1 RR024979 / NCRR NIH HHS R37 MH031593 / NIMH NIH HHS MH43271 / NIMH NIH HHS R01 MH080128-01A2 / NIMH NIH HHS K23 MH068380 / NIMH NIH HHS R01 MH040856-16 / NIMH NIH HHS
- Language
- English
- Date published
- 03/05/2010
- Academic Unit
- Psychiatry; Stead Family Department of Pediatrics; Iowa Neuroscience Institute
- Record Identifier
- 9984003425002771
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