Journal article
GABA and cortical inhibition in motor and non-motor regions using combined TMS-EEG: A time analysis
Clinical neurophysiology, Vol.120(9), pp.1706-1710
09/01/2009
DOI: 10.1016/j.clinph.2009.06.019
PMID: 19632893
Abstract
Objective: The induction of long interval cortical inhibition (LICI) in motor cortex with paired pulse transcranial magnetic stimulation (ppTMS) is an established paradigm for the assessment of cortical inhibition, proposed to be related to GABA(B) receptor inhibitory neurotransmission. This study aimed to further evaluate recent methods of the assessment of LICI in non motor regions with ppTMS and electroencephalography (EEG).
Methods: ppTMS was applied using a single coil to the motor and dorsolateral prefrontal cortex (DLPFC) in 14 healthy subjects, and in the parietal lobe in 5 of those subjects.
Results: In the motor cortex, LICI resulted in significant suppression in mean cortical evoked activity on EEG between 75 and 250 ms following delivery of the test stimulus. Maximal inhibition was seen from 50 to 250 ms in DLPFC, and between 50 and 175 ms in the parietal lobe. Conclusions: ppTMS may be used to produce LICI in several cortical regions with a time course similar to known GABA(B) activity.
Significance: ppTMS induction of LICI can be recorded by combining TMS with EEG and seems to relate to GABAB activity. (C) 2009 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.
Details
- Title: Subtitle
- GABA and cortical inhibition in motor and non-motor regions using combined TMS-EEG: A time analysis
- Creators
- Paul B. Fitzgerald - Monash UniversityJerome J. Maller - Monash UniversityKate Hoy - Monash UniversityFaranak Farzan - Centre for Addiction and Mental HealthZafiris J. Daskalakis - Centre for Addiction and Mental Health
- Resource Type
- Journal article
- Publication Details
- Clinical neurophysiology, Vol.120(9), pp.1706-1710
- DOI
- 10.1016/j.clinph.2009.06.019
- PMID
- 19632893
- NLM abbreviation
- Clin Neurophysiol
- ISSN
- 1388-2457
- eISSN
- 1872-8952
- Publisher
- Elsevier
- Number of pages
- 5
- Grant note
- Practitioner Fellowship (PBF); National Health & Medical Research Council (NHMRC) of Australia Young Investigator award (ZJD) Constance and Stephen Lieber through a National Alliance for Research on Schizophrenia and Depression (NARSAD); NARSAD National Health and Medical Research Council (NHMRC); National Health & Medical Research Council (NHMRC) of Australia
- Language
- English
- Date published
- 09/01/2009
- Academic Unit
- Radiology
- Record Identifier
- 9984848509602771
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