Journal article
GABAB receptor stimulation decreases amphetamine-induced behavior and neuropeptide gene expression in the striatum
Brain research, Vol.1004(1-2), pp.18-28
04/09/2004
DOI: 10.1016/j.brainres.2003.11.077
PMID: 15033416
Abstract
The purpose of this study was to investigate whether GABA(B) receptor activation blocks acute amphetamine-induced behavioral activity, dopamine release, and neuropeptide mRNA expression in the striatum. Systemic administration of R-(+)-baclofen (1.25 mg/kg, i.p.) did not alter total distance traveled or vertical rearing induced by amphetamine (2.5 mg/kg, i.p.). At 2.5 mg/kg, baclofen did not alter spontaneous motor activity or total distance traveled, but completely blocked vertical rearing induced by amphetamine. At 5.0 mg/kg, baclofen completely blocked both total distance traveled and vertical rearing induced by amphetamine. Quantitative in situ hybridization histochemistry revealed that baclofen (2.5 mg/kg, i.p.) decreased the ability of amphetamine to increase preprodynorphin (PPD), preprotachykinin (PPT), preproenkephalin (PPE), and secretogranin II (SGII) mRNA levels in the striatum without altering the basal levels of these signals. Baclofen also blocked the amphetamine-induced rise in SGII mRNA in the core and shell of the nucleus accumbens and cingulate cortex. In a separate experiment, systemic baclofen (2.5 mg/kg) decreased the amphetamine-induced increase in dialysate dopamine levels in the striatum. These results suggest that reduced striatal dopamine release contributes to the ability of GABA(B) receptor activation to decrease acute amphetamine-induced behavioral activity and striatal neuropeptide gene expression.
Details
- Title: Subtitle
- GABAB receptor stimulation decreases amphetamine-induced behavior and neuropeptide gene expression in the striatum
- Creators
- Wenxia Zhou - Medical University of South CarolinaAdam W Mailloux - Medical University of South CarolinaBruce J Jung - Medical University of South CarolinaHayward S Edmunds - Medical University of South CarolinaJacqueline F McGinty - Medical University of South Carolina
- Resource Type
- Journal article
- Publication Details
- Brain research, Vol.1004(1-2), pp.18-28
- DOI
- 10.1016/j.brainres.2003.11.077
- PMID
- 15033416
- ISSN
- 0006-8993
- eISSN
- 1872-6240
- Language
- English
- Date published
- 04/09/2004
- Academic Unit
- Microbiology and Immunology
- Record Identifier
- 9984297325502771
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