Journal article
GABAergic synaptic current in dissociated nucleus basalis of Meynert neurons of the rat
Brain research, Vol.570(1), pp.102-108
1992
DOI: 10.1016/0006-8993(92)90569-U
PMID: 1319789
Abstract
γ-Aminobutyric acid (GABA)-mediated spontaneous inhibitory postsynaptic currents (IPSCs) were recorded from dissociated rat nucleus basalis of Meynert neurons which still had their synaptic boutons attached. The membrane currents were recorded by the whole-cell patchcalmp technique. Elevated extracellular K
+ concentration and the addition of the calcium ionophore, A23187, enhanced the amplitude and frequency of spontaneous IPSCs. Ryanodine and Ca
2-free external solution containing EGTA or BAPTA markedly decreased the spontaneous IPSC activities. Spontaneous IPSC activities were reversibly reduced by baclofen and increased by phaclofen, indicating that the GABA
B receptor regulates the release of GABA from nerve terminals and acts as a negative autoreceptor.
Details
- Title: Subtitle
- GABAergic synaptic current in dissociated nucleus basalis of Meynert neurons of the rat
- Creators
- Norio AkaikeNobutoshi HarataShinya UenoNarito Tateishi
- Resource Type
- Journal article
- Publication Details
- Brain research, Vol.570(1), pp.102-108
- Publisher
- Elsevier B.V
- DOI
- 10.1016/0006-8993(92)90569-U
- PMID
- 1319789
- ISSN
- 0006-8993
- eISSN
- 1872-6240
- Language
- English
- Date published
- 1992
- Academic Unit
- Molecular Physiology and Biophysics
- Record Identifier
- 9984025325002771
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