Journal article
GABA$_{\text{A}}$-Receptor Function in Hippocampal Cells is Maintained by Phosphorylation Factors
Science (American Association for the Advancement of Science), Vol.241(4863), pp.339-341
07/15/1988
DOI: 10.1126/science.2455347
PMID: 2455347
Abstract
Gamma aminobutyric acid (GABA) mediates fast synaptic inhibition in the central nervous system by activating the chloride-permeable GABA$_{\text{A}}$ channel. The GABA$_{\text{A}}$ conductance progressively diminishes with time when the intracellular contents of hippocampal neurons are perfused with a minimal intracellular medium. This ``run down'' of the GABA-activated conductance can be prevented by the inclusion of magnesium adenosine triphosphate and calcium buffer in the intracellular medium. The amount of chloride conductance that can be activated by GABA is determined by competition between a calcium-dependent process that reduces the conductance and a phosphorylation process that maintains the conductance.
Details
- Title: Subtitle
- GABA$_{\text{A}}$-Receptor Function in Hippocampal Cells is Maintained by Phosphorylation Factors
- Creators
- Armin StelzerAlan R. Kay - University of Iowa, Iowa Neuroscience InstituteRobert K. S. Wong
- Resource Type
- Journal article
- Publication Details
- Science (American Association for the Advancement of Science), Vol.241(4863), pp.339-341
- Publisher
- The American Association for the Advancement of Science
- DOI
- 10.1126/science.2455347
- PMID
- 2455347
- ISSN
- 0036-8075
- eISSN
- 1095-9203
- Language
- English
- Date published
- 07/15/1988
- Academic Unit
- Iowa Neuroscience Institute; Biology
- Record Identifier
- 9984068242202771
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