Journal article
GATA-3 Expression as a Predictor of Hormone Response in Breast Cancer
Journal of the American College of Surgeons, Vol.200(5), pp.705-710
2005
DOI: 10.1016/j.jamcollsurg.2004.12.025
PMID: 15848360
Abstract
Expression of estrogen receptor-α (ERα) as determined by immunohistochemistry of tumor tissue is currently the most clinically useful test to predict hormone responsiveness of breast cancer. Thirty percent of ERα-positive breast cancers do not respond to hormonal therapy. GATA-3 is a transcription factor that is expressed in association with ERα and there is evidence that GATA factors influence response to estrogen. In this pilot study, we investigated whether GATA-3 expression is associated with hormone response in breast cancer.
Breast cancer tissue was stained for GATA-3 expression by immunohistochemistry in ERα-positive cancers from 28 patients, 14 of whom were defined as hormone unresponsive (cases) and 14 of whom were age-matched controls with hormone-responsive, ERα-positive cancers (controls).
Comparing cases and controls, there were no differences in expression of ERα; progesterone receptor, ErbB2; or tumor grade. Using 20% nuclear staining to characterize tumors as GATA-3 positive or GATA-3 negative, 6 of 14 (43%) cancers in the hormone-unresponsive group and none of the controls were classified as GATA-3 negative (odds ratio, 8.2; 95% confidence interval, 1.2−∞; p = 0.031). Using different cut points to characterize GATA-3 positivity yielded very similar results, indicating a positive association between lack of GATA-3 expression and lack of response to hormonal therapy.
The study suggests that analyzing ERα-positive breast tumors for GATA-3 using immunohistochemistry might improve prediction of hormone responsiveness. The association between GATA-3 expression and hormone response suggests that GATA-3 may play a role in mechanisms controlling response to estrogen.
Details
- Title: Subtitle
- GATA-3 Expression as a Predictor of Hormone Response in Breast Cancer
- Creators
- Purvi Parikh - Thomas Jefferson UniversityJuan P. Palazzo - Thomas Jefferson UniversityLewis J. Rose - Thomas Jefferson UniversityConstantine Daskalakis - Thomas Jefferson UniversityRonald J. Weigel - Thomas Jefferson University
- Resource Type
- Journal article
- Publication Details
- Journal of the American College of Surgeons, Vol.200(5), pp.705-710
- DOI
- 10.1016/j.jamcollsurg.2004.12.025
- PMID
- 15848360
- NLM abbreviation
- J Am Coll Surg
- ISSN
- 1072-7515
- eISSN
- 1879-1190
- Publisher
- Elsevier Inc
- Language
- English
- Date published
- 2005
- Academic Unit
- Molecular Physiology and Biophysics; Anatomy and Cell Biology; Surgery; Biochemistry and Molecular Biology
- Record Identifier
- 9984284336202771
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