Journal article
GATA-3 as a Marker of Hormone Response in Breast Cancer
The Journal of surgical research, Vol.157(2), pp.290-295
2009
DOI: 10.1016/j.jss.2008.07.015
PMID: 19059610
Abstract
GATA-3 is a transcription factor that orchestrates gene expression profiles during embryogenesis of a variety of human tissues, including hematopoietic cells, skin, kidney, mammary gland, and the central nervous system. Among several other roles, GATA-3 has recently been identified as a key player of luminal cell differentiation in the mammary gland. The majority of breast cancers arise from luminal epithelial cells and hence GATA-3 appears to control a set of genes involved in the differentiation and proliferation of breast cancer. The expression of GATA-3 has a strong association with the expression of estrogen receptor-α (ER) in breast cancer, and there is mounting evidence that GATA-3 can be used as a clinical marker to determine response to hormonal therapy and to refine the prognosis of breast cancer patients. Here, we review the literature from the past 10 y on GATA-3 in normal and pathological states of the mammary gland. Conclusions from the literature are confirmed using meta-analyses performed by the Oncomine Research Platform.
Details
- Title: Subtitle
- GATA-3 as a Marker of Hormone Response in Breast Cancer
- Creators
- Sandy H FangYizhen ChenRonald J Weigel
- Resource Type
- Journal article
- Publication Details
- The Journal of surgical research, Vol.157(2), pp.290-295
- Publisher
- Elsevier Inc
- DOI
- 10.1016/j.jss.2008.07.015
- PMID
- 19059610
- ISSN
- 0022-4804
- eISSN
- 1095-8673
- Language
- English
- Date published
- 2009
- Academic Unit
- Molecular Physiology and Biophysics; Anatomy and Cell Biology; Surgery; Biochemistry and Molecular Biology
- Record Identifier
- 9984024557502771
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